Mena, a new available marker in tumors of salivary glands?

S. Gurzu, M. Krause, I. Ember, L. Azamfirei, G. Gobel, K. Feher, I. Jung

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Mena (mammalian Ena) is an actin regulatory protein involved in cell motility and adhesion. Based on its potential role in malignant transformation revealed in other organs, we analyzed the Mena expression in normal salivary glands (SG) and salivary tumors. Mena expression was determined in normal SG (n=10) and also benign (n=20) and malignant (n=35) lesions of SG. For the immunohistochemical staining we used the anti-Mena antibody. All normal SG and the benign lesions (10 pleomorphic adenomas, 10 Warthin's tumors) were Mena negative. Salivary duct carcinomas (n=5), carcinomas in pleomorphic adenoma (n=5), acinic cell carcinomas (n=5), squamous cell carcinomas (n=10) and high-grade mucoepidermoid carcinomas (n=2) were positive. The lymphomas (n=5) and low-grade mucoepidermoid carcinomas (n=1) were Mena negative. In one case the lymphoblastic cells stained positive for Mena. Some of the endothelial cells, in the peritumoral vessels, were Mena positive. To the best of our knowledge, this is the first study in the literature about Mena expression in salivary tumors. Our study suggests that Mena protein seems to play a role in malignant transformation and its intensity is correlated with the type and grade of tumor and also with vascular invasion. Its positivity in endothelial cells may suggest its potential role in tumor angiogenesis.

Original languageEnglish
JournalEuropean Journal of Histochemistry
Volume56
Issue number1
Publication statusPublished - 2012

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Tumor Biomarkers
Salivary Glands
Mucoepidermoid Carcinoma
Pleomorphic Adenoma
Neoplasms
Endothelial Cells
Adenolymphoma
Acinar Cell Carcinoma
Salivary Ducts
Carcinoma
Cell Adhesion
Cell Movement
Blood Vessels
Actins
Squamous Cell Carcinoma
Lymphoma
Staining and Labeling
Antibodies
Proteins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gurzu, S., Krause, M., Ember, I., Azamfirei, L., Gobel, G., Feher, K., & Jung, I. (2012). Mena, a new available marker in tumors of salivary glands? European Journal of Histochemistry, 56(1).

Mena, a new available marker in tumors of salivary glands? / Gurzu, S.; Krause, M.; Ember, I.; Azamfirei, L.; Gobel, G.; Feher, K.; Jung, I.

In: European Journal of Histochemistry, Vol. 56, No. 1, 2012.

Research output: Contribution to journalArticle

Gurzu, S, Krause, M, Ember, I, Azamfirei, L, Gobel, G, Feher, K & Jung, I 2012, 'Mena, a new available marker in tumors of salivary glands?', European Journal of Histochemistry, vol. 56, no. 1.
Gurzu S, Krause M, Ember I, Azamfirei L, Gobel G, Feher K et al. Mena, a new available marker in tumors of salivary glands? European Journal of Histochemistry. 2012;56(1).
Gurzu, S. ; Krause, M. ; Ember, I. ; Azamfirei, L. ; Gobel, G. ; Feher, K. ; Jung, I. / Mena, a new available marker in tumors of salivary glands?. In: European Journal of Histochemistry. 2012 ; Vol. 56, No. 1.
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