Membrane vesicles, current state-of-the-art: Emerging role of extracellular vesicles

Bence György, Tamás G. Szabó, Mária Pásztói, Zsuzsanna Pál, Petra Misják, Borbála Aradi, V. László, E. Pállinger, Erna Pap, A. Kittel, György Nagy, A. Falus, E. Búzás

Research output: Contribution to journalArticle

958 Citations (Scopus)

Abstract

Release of membrane vesicles, a process conserved in both prokaryotes and eukaryotes, represents an evolutionary link, and suggests essential functions of a dynamic extracellular vesicular compartment (including exosomes, microparticles or microvesicles and apoptotic bodies). Compelling evidence supports the significance of this compartment in a broad range of physiological and pathological processes. However, classification of membrane vesicles, protocols of their isolation and detection, molecular details of vesicular release, clearance and biological functions are still under intense investigation. Here, we give a comprehensive overview of extracellular vesicles. After discussing the technical pitfalls and potential artifacts of the rapidly emerging field, we compare results from meta-analyses of published proteomic studies on membrane vesicles. We also summarize clinical implications of membrane vesicles. Lessons from this compartment challenge current paradigms concerning the mechanisms of intercellular communication and immune regulation. Furthermore, its clinical implementation may open new perspectives in translational medicine both in diagnostics and therapy.

Original languageEnglish
Pages (from-to)2667-2688
Number of pages22
JournalCellular and Molecular Life Sciences
Volume68
Issue number16
DOIs
Publication statusPublished - Aug 2011

Fingerprint

Membranes
Physiological Phenomena
Exosomes
Translational Medical Research
Pathologic Processes
Eukaryota
Proteomics
Artifacts
Meta-Analysis
Extracellular Vesicles
Therapeutics

Keywords

  • Apoptotic body
  • Autoimmune disease
  • Biomarker
  • Cancer
  • Exosome
  • Microparticle
  • Microvesicle
  • Platelet

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Molecular Medicine
  • Pharmacology
  • Cellular and Molecular Neuroscience

Cite this

Membrane vesicles, current state-of-the-art : Emerging role of extracellular vesicles. / György, Bence; Szabó, Tamás G.; Pásztói, Mária; Pál, Zsuzsanna; Misják, Petra; Aradi, Borbála; László, V.; Pállinger, E.; Pap, Erna; Kittel, A.; Nagy, György; Falus, A.; Búzás, E.

In: Cellular and Molecular Life Sciences, Vol. 68, No. 16, 08.2011, p. 2667-2688.

Research output: Contribution to journalArticle

György, Bence ; Szabó, Tamás G. ; Pásztói, Mária ; Pál, Zsuzsanna ; Misják, Petra ; Aradi, Borbála ; László, V. ; Pállinger, E. ; Pap, Erna ; Kittel, A. ; Nagy, György ; Falus, A. ; Búzás, E. / Membrane vesicles, current state-of-the-art : Emerging role of extracellular vesicles. In: Cellular and Molecular Life Sciences. 2011 ; Vol. 68, No. 16. pp. 2667-2688.
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