Membrane-targeting of signalling molecules by SH2/SH3 domain-containing adaptor proteins

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

SH2/SH3 domain-containing adaptor proteins play a critical role in regulating tyrosine kinase signalling pathways. The major function of these adaptors, such as Grb2, Nck, and Crk, is to recruit proline-rich effector molecules to tyrosine-phosphorylated kinases or their substrates. In recent years dozens of novel proteins have emerged that are capable of associating with the SH2 and the SH3 domains of adaptors. In this review, the author attempts to summarise these novel binding partners of Grb2, Nck, and Crk, and to discuss current controversies regarding function and regulation of protein multicomplexes held together by SH2/SH3 adaptor molecules at the plasma membrane. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)187-204
Number of pages18
JournalBBA - Reviews on Biomembranes
Volume1422
Issue number2
DOIs
Publication statusPublished - Jul 6 1999

Fingerprint

src Homology Domains
Membranes
Protein-Tyrosine Kinases
Proteins
Proline
Cell Membrane

Keywords

  • Cbl
  • Crk
  • Grb2
  • Nck
  • SH2/SH3 domains
  • Sos

ASJC Scopus subject areas

  • Cell Biology
  • Biophysics

Cite this

Membrane-targeting of signalling molecules by SH2/SH3 domain-containing adaptor proteins. / Buday, L.

In: BBA - Reviews on Biomembranes, Vol. 1422, No. 2, 06.07.1999, p. 187-204.

Research output: Contribution to journalArticle

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