Membrane stretch and salivary glands - Facts and theories

T. Zelles, I. Boros, G. Varga

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Cell shape in salivary glands is affected by mechanical forces. In the acini and ducts cell shape is modified by the contractions of the myoepithelial cells in both the secretary and ductal portions of the glands. At the organ level shape changes are due to muscle contraction during mastication, food intake and speech. All these factors may cause some degree of stretching of salivary cell membranes. Recent studies suggest that physical forces influence signal transduction, gene expression, secretary function, cell differentiation and proliferation. Here we overview membrane stretch-activated cellular events. Evidence from a variety of tissues suggests that mechanical forces may alter the properties of acinar cells leading to cytoskeletal reorganisation, changes in ion fluxes, modulation at secretary activity and subsequent release of transmitters such as ATP. Transmitters released from acinar cells may modulate the secretary activity of salivary tissue, and interact with classical regulatory pathways.

Original languageEnglish
JournalArchives of Oral Biology
Volume44
Issue numberSUPPL. 1
DOIs
Publication statusPublished - May 1999

Fingerprint

Acinar Cells
Salivary Glands
Cell Shape
Membranes
Mastication
Muscle Contraction
Cell Differentiation
Signal Transduction
Eating
Adenosine Triphosphate
Cell Proliferation
Cell Membrane
Ions
Gene Expression

Keywords

  • Force transduction
  • Mechanical force
  • Membrane stretch
  • Myoepithelial cell
  • Salivary glands

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Membrane stretch and salivary glands - Facts and theories. / Zelles, T.; Boros, I.; Varga, G.

In: Archives of Oral Biology, Vol. 44, No. SUPPL. 1, 05.1999.

Research output: Contribution to journalArticle

@article{cc3581708db744099ac28b55670a68e4,
title = "Membrane stretch and salivary glands - Facts and theories",
abstract = "Cell shape in salivary glands is affected by mechanical forces. In the acini and ducts cell shape is modified by the contractions of the myoepithelial cells in both the secretary and ductal portions of the glands. At the organ level shape changes are due to muscle contraction during mastication, food intake and speech. All these factors may cause some degree of stretching of salivary cell membranes. Recent studies suggest that physical forces influence signal transduction, gene expression, secretary function, cell differentiation and proliferation. Here we overview membrane stretch-activated cellular events. Evidence from a variety of tissues suggests that mechanical forces may alter the properties of acinar cells leading to cytoskeletal reorganisation, changes in ion fluxes, modulation at secretary activity and subsequent release of transmitters such as ATP. Transmitters released from acinar cells may modulate the secretary activity of salivary tissue, and interact with classical regulatory pathways.",
keywords = "Force transduction, Mechanical force, Membrane stretch, Myoepithelial cell, Salivary glands",
author = "T. Zelles and I. Boros and G. Varga",
year = "1999",
month = "5",
doi = "10.1016/S0003-9969(99)00054-0",
language = "English",
volume = "44",
journal = "Archives of Oral Biology",
issn = "0003-9969",
publisher = "Elsevier Limited",
number = "SUPPL. 1",

}

TY - JOUR

T1 - Membrane stretch and salivary glands - Facts and theories

AU - Zelles, T.

AU - Boros, I.

AU - Varga, G.

PY - 1999/5

Y1 - 1999/5

N2 - Cell shape in salivary glands is affected by mechanical forces. In the acini and ducts cell shape is modified by the contractions of the myoepithelial cells in both the secretary and ductal portions of the glands. At the organ level shape changes are due to muscle contraction during mastication, food intake and speech. All these factors may cause some degree of stretching of salivary cell membranes. Recent studies suggest that physical forces influence signal transduction, gene expression, secretary function, cell differentiation and proliferation. Here we overview membrane stretch-activated cellular events. Evidence from a variety of tissues suggests that mechanical forces may alter the properties of acinar cells leading to cytoskeletal reorganisation, changes in ion fluxes, modulation at secretary activity and subsequent release of transmitters such as ATP. Transmitters released from acinar cells may modulate the secretary activity of salivary tissue, and interact with classical regulatory pathways.

AB - Cell shape in salivary glands is affected by mechanical forces. In the acini and ducts cell shape is modified by the contractions of the myoepithelial cells in both the secretary and ductal portions of the glands. At the organ level shape changes are due to muscle contraction during mastication, food intake and speech. All these factors may cause some degree of stretching of salivary cell membranes. Recent studies suggest that physical forces influence signal transduction, gene expression, secretary function, cell differentiation and proliferation. Here we overview membrane stretch-activated cellular events. Evidence from a variety of tissues suggests that mechanical forces may alter the properties of acinar cells leading to cytoskeletal reorganisation, changes in ion fluxes, modulation at secretary activity and subsequent release of transmitters such as ATP. Transmitters released from acinar cells may modulate the secretary activity of salivary tissue, and interact with classical regulatory pathways.

KW - Force transduction

KW - Mechanical force

KW - Membrane stretch

KW - Myoepithelial cell

KW - Salivary glands

UR - http://www.scopus.com/inward/record.url?scp=0033136655&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033136655&partnerID=8YFLogxK

U2 - 10.1016/S0003-9969(99)00054-0

DO - 10.1016/S0003-9969(99)00054-0

M3 - Article

VL - 44

JO - Archives of Oral Biology

JF - Archives of Oral Biology

SN - 0003-9969

IS - SUPPL. 1

ER -