Membrane-regulated stress response: A theoretical and practical approach

Research output: Chapter in Book/Report/Conference proceedingChapter

39 Citations (Scopus)

Abstract

A number of observations have lent support to a model in which thermal stress is transduced into a signal at the level of the cellular membranes. Our alternative, but not exclusive, approach is based on the concept that the initial stress-sensing events are associated with the physical state and lipid composition of cellular membranes, i.e., the subde alteration(s) of membrane fluidity, phase state, and/or microheterogeneity may operate as a cellular thermometer. In fact, various pathological states and aging are associated with typical "membrane defects" and simultaneous dysregulation of heat shock protein synthesis. The discovery of nonproteotoxic membrane-lipid interacting compounds, capable of modulating membrane microdomains engaged in primary stress sensing may be of paramount importance for the design of new drugs with the ability to induce or attenuate the level of particular heat shock proteins.

Original languageEnglish
Title of host publicationMolecular Aspects of the Stress Response
Subtitle of host publicationChaperones, Membranes and Networks
PublisherSpringer New York
Pages114-131
Number of pages18
ISBN (Print)9780387399744
DOIs
Publication statusPublished - Jan 1 2007

Publication series

NameAdvances in Experimental Medicine and Biology
Volume594
ISSN (Print)0065-2598

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Vígh, L., Török, Z., Balogh, G., Glatz, A., Piotto, S., & Horváth, I. (2007). Membrane-regulated stress response: A theoretical and practical approach. In Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks (pp. 114-131). (Advances in Experimental Medicine and Biology; Vol. 594). Springer New York. https://doi.org/10.1007/978-0-387-39975-1_11