Membrane phospholipid and fatty acid changes in the mitochondrial and sarcolemmal fractions of the heart in adjuvant arthritic rats

Gy Nemecz, P. Bor, I. Leprán, M. Koltai, L. Szekeres

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Adjuvant arthritis was found to induce changes in phospholipid and fatty acid composition as well as in membrane fluidity of mitochondrial and sarcolemmal fractions in the rat heart. In the sarcolemmal fraction, phosphatidylcholine content was decreased, while phosphatidylserine, phosphatidylinositol and the lysocompounds of phospholipids were increased. Mitochondria isolated from the heart of rats with adjuvant disease contained less linoleic acid than control samples. Docosatetraenoic acid and docosahexaenoic acid levels were shown to be increased in both mitochondrial and sarcolemmal fractions of the heart in treated animals. Electron spin resonance studies indicated that the break points of the curves obtained by plotting the order parameters against temperature changes were slightly shifted to lower temperature region in both subcellular fractions of arthritic rat hearts. As compared to the control values, membrane fluidity was increased both in mitochondrial and sarcolemmal fractions. The relationship of these alterations to our previous findings that adjuvant arthritis protected the rats against fatal post-infarctions arrhythmias needs further elucidation.

Original languageEnglish
Pages (from-to)739-747
Number of pages9
JournalJournal of Molecular and Cellular Cardiology
Volume18
Issue number7
DOIs
Publication statusPublished - Jul 1986

Keywords

  • Adjuvant arthritis
  • Fatty acids
  • Membrane fluidity
  • Mitochondria
  • Phospholipids
  • Rat heart
  • Sarcolemma

ASJC Scopus subject areas

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine

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