Membrane lipid therapy

Modulation of the cell membrane composition and structure as a molecular base for drug discovery and new disease treatment

Pablo V. Escribá, Xavier Busquets, Jin Ichi Inokuchi, G. Balogh, Z. Török, I. Horváth, John L. Harwood, L. Vígh

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Nowadays we understand cell membranes not as a simple double lipid layer but as a collection of complex and dynamic protein-lipid structures and microdomains that serve as functional platforms for interacting signaling lipids and proteins. Membrane lipids and lipid structures participate directly as messengers or regulators of signal transduction. In addition, protein-lipid interactions participate in the localization of signaling protein partners to specific membrane microdomains. Thus, lipid alterations change cell signaling that are associated with a variety of diseases including cancer, obesity, neurodegenerative disorders, cardiovascular pathologies, etc. This article reviews the newly emerging field of membrane lipid therapy which involves the pharmacological regulation of membrane lipid composition and structure for the treatment of diseases. Membrane lipid therapy proposes the use of new molecules specifically designed to modify membrane lipid structures and microdomains as pharmaceutical disease-modifying agents by reversing the malfunction or altering the expression of disease-specific protein or lipid signal cascades. Here, we provide an in-depth analysis of this emerging field, especially its molecular bases and its relevance to the development of innovative therapeutic approaches.

Original languageEnglish
Pages (from-to)38-53
Number of pages16
JournalProgress in Lipid Research
Volume59
DOIs
Publication statusPublished - Jun 11 2015

Fingerprint

Cell Membrane Structures
Drug Discovery
Cell membranes
Membrane Lipids
Modulation
Lipids
Chemical analysis
Membrane Microdomains
Proteins
Therapeutics
Cell signaling
Signal transduction
Pathology
Neurodegenerative Diseases
Signal Transduction
Obesity
Cell Membrane
Pharmacology
Membranes
Molecules

Keywords

  • G protein-membrane interactions
  • Membrane cell signaling
  • Membrane lipid structure
  • Membrane-lipid therapy drugs
  • Membrane-protein interactions

ASJC Scopus subject areas

  • Cell Biology
  • Biochemistry

Cite this

Membrane lipid therapy : Modulation of the cell membrane composition and structure as a molecular base for drug discovery and new disease treatment. / Escribá, Pablo V.; Busquets, Xavier; Inokuchi, Jin Ichi; Balogh, G.; Török, Z.; Horváth, I.; Harwood, John L.; Vígh, L.

In: Progress in Lipid Research, Vol. 59, 11.06.2015, p. 38-53.

Research output: Contribution to journalArticle

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