Membrane fluidity matters: Hyperthermia from the aspects of lipids and membranes

Balint Csoboz, G. Balogh, E. Kúsz, I. Gombos, Maria Peter, Tim Crul, Burcin Gungor, L. Haracska, Gordana Bogdanovics, Z. Török, I. Horváth, L. Vígh

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Hyperthermia is a promising treatment modality for cancer in combination both with radio- and chemotherapy. In spite of its great therapeutic potential, the underlying molecular mechanisms still remain to be clarified. Due to lipid imbalances and 'membrane defects' most of the tumour cells possess elevated membrane fluidity. However, further increasing membrane fluidity to sensitise to chemo- or radiotherapy could have some other effects. In fact, hyperfluidisation of cell membrane induced by membrane fluidiser initiates a stress response as the heat shock protein response, which may modulate positively or negatively apoptotic cell death. Overviewing some recent findings based on a technology allowing direct imaging of lipid rafts in live cells and lipidomics, novel aspects of the intimate relationship between the 'membrane stress' of tumour cells and the cellular heat shock response will be highlighted. Our findings lend support to both the importance of membrane remodelling and the release of lipid signals initiating stress protein response, which can operate in tandem to control the extent of the ultimate cellular thermosensitivity. Overall, we suggest that the fluidity variable of membranes should be used as an independent factor for predicting the efficacy of combinational cancer therapies.

Original languageEnglish
Pages (from-to)491-499
Number of pages9
JournalInternational Journal of Hyperthermia
Volume29
Issue number5
DOIs
Publication statusPublished - Aug 2013

Fingerprint

Membrane Fluidity
Membrane Lipids
Fever
Heat-Shock Response
Heat-Shock Proteins
Membranes
Neoplasms
Radiotherapy
Lipids
Drug Therapy
Cell Death
Therapeutics
Cell Membrane
Technology

Keywords

  • Cancer therapy
  • Heat shock protein
  • Hyperthermia
  • Lipid raft
  • Membrane fluidity
  • Thermotolerance

ASJC Scopus subject areas

  • Cancer Research
  • Physiology
  • Radiological and Ultrasound Technology
  • Physiology (medical)

Cite this

Membrane fluidity matters : Hyperthermia from the aspects of lipids and membranes. / Csoboz, Balint; Balogh, G.; Kúsz, E.; Gombos, I.; Peter, Maria; Crul, Tim; Gungor, Burcin; Haracska, L.; Bogdanovics, Gordana; Török, Z.; Horváth, I.; Vígh, L.

In: International Journal of Hyperthermia, Vol. 29, No. 5, 08.2013, p. 491-499.

Research output: Contribution to journalArticle

@article{28f67699b88547688b2f9f84ee71aca9,
title = "Membrane fluidity matters: Hyperthermia from the aspects of lipids and membranes",
abstract = "Hyperthermia is a promising treatment modality for cancer in combination both with radio- and chemotherapy. In spite of its great therapeutic potential, the underlying molecular mechanisms still remain to be clarified. Due to lipid imbalances and 'membrane defects' most of the tumour cells possess elevated membrane fluidity. However, further increasing membrane fluidity to sensitise to chemo- or radiotherapy could have some other effects. In fact, hyperfluidisation of cell membrane induced by membrane fluidiser initiates a stress response as the heat shock protein response, which may modulate positively or negatively apoptotic cell death. Overviewing some recent findings based on a technology allowing direct imaging of lipid rafts in live cells and lipidomics, novel aspects of the intimate relationship between the 'membrane stress' of tumour cells and the cellular heat shock response will be highlighted. Our findings lend support to both the importance of membrane remodelling and the release of lipid signals initiating stress protein response, which can operate in tandem to control the extent of the ultimate cellular thermosensitivity. Overall, we suggest that the fluidity variable of membranes should be used as an independent factor for predicting the efficacy of combinational cancer therapies.",
keywords = "Cancer therapy, Heat shock protein, Hyperthermia, Lipid raft, Membrane fluidity, Thermotolerance",
author = "Balint Csoboz and G. Balogh and E. K{\'u}sz and I. Gombos and Maria Peter and Tim Crul and Burcin Gungor and L. Haracska and Gordana Bogdanovics and Z. T{\"o}r{\"o}k and I. Horv{\'a}th and L. V{\'i}gh",
year = "2013",
month = "8",
doi = "10.3109/02656736.2013.808765",
language = "English",
volume = "29",
pages = "491--499",
journal = "International Journal of Hyperthermia",
issn = "0265-6736",
publisher = "Informa Healthcare",
number = "5",

}

TY - JOUR

T1 - Membrane fluidity matters

T2 - Hyperthermia from the aspects of lipids and membranes

AU - Csoboz, Balint

AU - Balogh, G.

AU - Kúsz, E.

AU - Gombos, I.

AU - Peter, Maria

AU - Crul, Tim

AU - Gungor, Burcin

AU - Haracska, L.

AU - Bogdanovics, Gordana

AU - Török, Z.

AU - Horváth, I.

AU - Vígh, L.

PY - 2013/8

Y1 - 2013/8

N2 - Hyperthermia is a promising treatment modality for cancer in combination both with radio- and chemotherapy. In spite of its great therapeutic potential, the underlying molecular mechanisms still remain to be clarified. Due to lipid imbalances and 'membrane defects' most of the tumour cells possess elevated membrane fluidity. However, further increasing membrane fluidity to sensitise to chemo- or radiotherapy could have some other effects. In fact, hyperfluidisation of cell membrane induced by membrane fluidiser initiates a stress response as the heat shock protein response, which may modulate positively or negatively apoptotic cell death. Overviewing some recent findings based on a technology allowing direct imaging of lipid rafts in live cells and lipidomics, novel aspects of the intimate relationship between the 'membrane stress' of tumour cells and the cellular heat shock response will be highlighted. Our findings lend support to both the importance of membrane remodelling and the release of lipid signals initiating stress protein response, which can operate in tandem to control the extent of the ultimate cellular thermosensitivity. Overall, we suggest that the fluidity variable of membranes should be used as an independent factor for predicting the efficacy of combinational cancer therapies.

AB - Hyperthermia is a promising treatment modality for cancer in combination both with radio- and chemotherapy. In spite of its great therapeutic potential, the underlying molecular mechanisms still remain to be clarified. Due to lipid imbalances and 'membrane defects' most of the tumour cells possess elevated membrane fluidity. However, further increasing membrane fluidity to sensitise to chemo- or radiotherapy could have some other effects. In fact, hyperfluidisation of cell membrane induced by membrane fluidiser initiates a stress response as the heat shock protein response, which may modulate positively or negatively apoptotic cell death. Overviewing some recent findings based on a technology allowing direct imaging of lipid rafts in live cells and lipidomics, novel aspects of the intimate relationship between the 'membrane stress' of tumour cells and the cellular heat shock response will be highlighted. Our findings lend support to both the importance of membrane remodelling and the release of lipid signals initiating stress protein response, which can operate in tandem to control the extent of the ultimate cellular thermosensitivity. Overall, we suggest that the fluidity variable of membranes should be used as an independent factor for predicting the efficacy of combinational cancer therapies.

KW - Cancer therapy

KW - Heat shock protein

KW - Hyperthermia

KW - Lipid raft

KW - Membrane fluidity

KW - Thermotolerance

UR - http://www.scopus.com/inward/record.url?scp=84881121802&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84881121802&partnerID=8YFLogxK

U2 - 10.3109/02656736.2013.808765

DO - 10.3109/02656736.2013.808765

M3 - Article

C2 - 23841917

AN - SCOPUS:84881121802

VL - 29

SP - 491

EP - 499

JO - International Journal of Hyperthermia

JF - International Journal of Hyperthermia

SN - 0265-6736

IS - 5

ER -