Membrane affinity of new antitubercular drug candidates using a phospholipid langmuir monolayer model and LB technique

D. Schnöller, Cs B. Pénzes, K. Horváti, Sz. Bősze, F. Hudecz, E. Kiss

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Citations (Scopus)

Abstract

Tuberculosis is a major problem throughout the world causing 1.9 million deaths annually, and induces a major global public health problem. The pathogen responsible for the disease is Mycobacterium tuberculosis. Drug candidates expected to be specific inhibitors of dUTPase an essential enzyme of Mycobacterium tuberculosis were identified in silico. A phospholipid Langmuir monolayer formed at the liquid/air interface as a simple but versatile model of the cell membrane was applied to assess the membrane affinity of the drug candidates. The interaction of three different potential drug molecules TB501, TB502, and TB505 with lipid monolayer was characterised by tensiometry, and atomic force microscopy at different temperatures. The degree of penetration of drug candidates into the lipid film and the structural variation of drug penetrated lipid films revealed by atomic force microscopic images were compared.

Original languageEnglish
Title of host publicationProgress in Colloid and Polymer Science
Pages131-138
Number of pages8
Volume138
DOIs
Publication statusPublished - 2010

Publication series

NameProgress in Colloid and Polymer Science
Volume138
ISSN (Print)0340255X

Fingerprint

Antitubercular Agents
monomolecular films
Phospholipids
Lipids
affinity
Monolayers
drugs
tuberculosis
membranes
Membranes
lipids
Pharmaceutical Preparations
Public health
Pathogens
Cell membranes
Medical problems
Atomic force microscopy
Enzymes
public health
liquid air

Keywords

  • AFM
  • Antituberculotics
  • Langmuir monolayer
  • LB film
  • Penetration

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry
  • Materials Chemistry
  • Polymers and Plastics

Cite this

Schnöller, D., Pénzes, C. B., Horváti, K., Bősze, S., Hudecz, F., & Kiss, E. (2010). Membrane affinity of new antitubercular drug candidates using a phospholipid langmuir monolayer model and LB technique. In Progress in Colloid and Polymer Science (Vol. 138, pp. 131-138). (Progress in Colloid and Polymer Science; Vol. 138). https://doi.org/10.1007/978-3-642-19038-4_23

Membrane affinity of new antitubercular drug candidates using a phospholipid langmuir monolayer model and LB technique. / Schnöller, D.; Pénzes, Cs B.; Horváti, K.; Bősze, Sz.; Hudecz, F.; Kiss, E.

Progress in Colloid and Polymer Science. Vol. 138 2010. p. 131-138 (Progress in Colloid and Polymer Science; Vol. 138).

Research output: Chapter in Book/Report/Conference proceedingChapter

Schnöller, D, Pénzes, CB, Horváti, K, Bősze, S, Hudecz, F & Kiss, E 2010, Membrane affinity of new antitubercular drug candidates using a phospholipid langmuir monolayer model and LB technique. in Progress in Colloid and Polymer Science. vol. 138, Progress in Colloid and Polymer Science, vol. 138, pp. 131-138. https://doi.org/10.1007/978-3-642-19038-4_23
Schnöller D, Pénzes CB, Horváti K, Bősze S, Hudecz F, Kiss E. Membrane affinity of new antitubercular drug candidates using a phospholipid langmuir monolayer model and LB technique. In Progress in Colloid and Polymer Science. Vol. 138. 2010. p. 131-138. (Progress in Colloid and Polymer Science). https://doi.org/10.1007/978-3-642-19038-4_23
Schnöller, D. ; Pénzes, Cs B. ; Horváti, K. ; Bősze, Sz. ; Hudecz, F. ; Kiss, E. / Membrane affinity of new antitubercular drug candidates using a phospholipid langmuir monolayer model and LB technique. Progress in Colloid and Polymer Science. Vol. 138 2010. pp. 131-138 (Progress in Colloid and Polymer Science).
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