Membrane affinity and antibacterial properties of cationic polyelectrolytes with different hydrophobicity

E. Kiss, Elisabeth T. Heine, Katalin Hill, Ying Chun He, Nina Keusgen, Csanád B. Pénzes, Donát Schnöller, Gergo A. Gyulai, Aleksandra Mendrek, Helmut Keul, Martin Moeller

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The antibacterial behavior of cationic polyelectrolytes is studied using model membrane experiments and in vitro bacterial investigations. The molecular interaction with lipid films is evaluated by the degree of penetration of the polymers into Langmuir monolayers of neutral or negatively charged lipids. The polymer/lipid interaction results in structural changes of the penetrated lipid layer visualized using AFM. The polymers are found to be effective in inhibiting the proliferation of E. coli, B. subtilis and S. aureus. The influence of the chemical structure on the functional behavior is related to the conformational properties. An optimum structure is identified on the basis of antibacterial and hemolytic tests as well as membrane-destroying efficacy of the antimicrobial polymers.

Original languageEnglish
Pages (from-to)1181-1189
Number of pages9
JournalMacromolecular Bioscience
Volume12
Issue number9
DOIs
Publication statusPublished - Sep 2012

Fingerprint

Hydrophobicity
Polyelectrolytes
Hydrophobic and Hydrophilic Interactions
Lipids
Polymers
Membranes
Molecular interactions
Escherichia coli
Monolayers
polycations
Experiments

Keywords

  • Antimicrobial properties
  • Functional polymers
  • Membrane affinity
  • Poly(ethylene imine)s
  • Polyamphiphiles

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

Cite this

Membrane affinity and antibacterial properties of cationic polyelectrolytes with different hydrophobicity. / Kiss, E.; Heine, Elisabeth T.; Hill, Katalin; He, Ying Chun; Keusgen, Nina; Pénzes, Csanád B.; Schnöller, Donát; Gyulai, Gergo A.; Mendrek, Aleksandra; Keul, Helmut; Moeller, Martin.

In: Macromolecular Bioscience, Vol. 12, No. 9, 09.2012, p. 1181-1189.

Research output: Contribution to journalArticle

Kiss, E, Heine, ET, Hill, K, He, YC, Keusgen, N, Pénzes, CB, Schnöller, D, Gyulai, GA, Mendrek, A, Keul, H & Moeller, M 2012, 'Membrane affinity and antibacterial properties of cationic polyelectrolytes with different hydrophobicity', Macromolecular Bioscience, vol. 12, no. 9, pp. 1181-1189. https://doi.org/10.1002/mabi.201200078
Kiss, E. ; Heine, Elisabeth T. ; Hill, Katalin ; He, Ying Chun ; Keusgen, Nina ; Pénzes, Csanád B. ; Schnöller, Donát ; Gyulai, Gergo A. ; Mendrek, Aleksandra ; Keul, Helmut ; Moeller, Martin. / Membrane affinity and antibacterial properties of cationic polyelectrolytes with different hydrophobicity. In: Macromolecular Bioscience. 2012 ; Vol. 12, No. 9. pp. 1181-1189.
@article{501ddb04000240e39206a9304ba2bd41,
title = "Membrane affinity and antibacterial properties of cationic polyelectrolytes with different hydrophobicity",
abstract = "The antibacterial behavior of cationic polyelectrolytes is studied using model membrane experiments and in vitro bacterial investigations. The molecular interaction with lipid films is evaluated by the degree of penetration of the polymers into Langmuir monolayers of neutral or negatively charged lipids. The polymer/lipid interaction results in structural changes of the penetrated lipid layer visualized using AFM. The polymers are found to be effective in inhibiting the proliferation of E. coli, B. subtilis and S. aureus. The influence of the chemical structure on the functional behavior is related to the conformational properties. An optimum structure is identified on the basis of antibacterial and hemolytic tests as well as membrane-destroying efficacy of the antimicrobial polymers.",
keywords = "Antimicrobial properties, Functional polymers, Membrane affinity, Poly(ethylene imine)s, Polyamphiphiles",
author = "E. Kiss and Heine, {Elisabeth T.} and Katalin Hill and He, {Ying Chun} and Nina Keusgen and P{\'e}nzes, {Csan{\'a}d B.} and Don{\'a}t Schn{\"o}ller and Gyulai, {Gergo A.} and Aleksandra Mendrek and Helmut Keul and Martin Moeller",
year = "2012",
month = "9",
doi = "10.1002/mabi.201200078",
language = "English",
volume = "12",
pages = "1181--1189",
journal = "Macromolecular Bioscience",
issn = "1616-5187",
publisher = "Wiley-VCH Verlag",
number = "9",

}

TY - JOUR

T1 - Membrane affinity and antibacterial properties of cationic polyelectrolytes with different hydrophobicity

AU - Kiss, E.

AU - Heine, Elisabeth T.

AU - Hill, Katalin

AU - He, Ying Chun

AU - Keusgen, Nina

AU - Pénzes, Csanád B.

AU - Schnöller, Donát

AU - Gyulai, Gergo A.

AU - Mendrek, Aleksandra

AU - Keul, Helmut

AU - Moeller, Martin

PY - 2012/9

Y1 - 2012/9

N2 - The antibacterial behavior of cationic polyelectrolytes is studied using model membrane experiments and in vitro bacterial investigations. The molecular interaction with lipid films is evaluated by the degree of penetration of the polymers into Langmuir monolayers of neutral or negatively charged lipids. The polymer/lipid interaction results in structural changes of the penetrated lipid layer visualized using AFM. The polymers are found to be effective in inhibiting the proliferation of E. coli, B. subtilis and S. aureus. The influence of the chemical structure on the functional behavior is related to the conformational properties. An optimum structure is identified on the basis of antibacterial and hemolytic tests as well as membrane-destroying efficacy of the antimicrobial polymers.

AB - The antibacterial behavior of cationic polyelectrolytes is studied using model membrane experiments and in vitro bacterial investigations. The molecular interaction with lipid films is evaluated by the degree of penetration of the polymers into Langmuir monolayers of neutral or negatively charged lipids. The polymer/lipid interaction results in structural changes of the penetrated lipid layer visualized using AFM. The polymers are found to be effective in inhibiting the proliferation of E. coli, B. subtilis and S. aureus. The influence of the chemical structure on the functional behavior is related to the conformational properties. An optimum structure is identified on the basis of antibacterial and hemolytic tests as well as membrane-destroying efficacy of the antimicrobial polymers.

KW - Antimicrobial properties

KW - Functional polymers

KW - Membrane affinity

KW - Poly(ethylene imine)s

KW - Polyamphiphiles

UR - http://www.scopus.com/inward/record.url?scp=84865739845&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84865739845&partnerID=8YFLogxK

U2 - 10.1002/mabi.201200078

DO - 10.1002/mabi.201200078

M3 - Article

C2 - 22833349

AN - SCOPUS:84865739845

VL - 12

SP - 1181

EP - 1189

JO - Macromolecular Bioscience

JF - Macromolecular Bioscience

SN - 1616-5187

IS - 9

ER -