Melt-blown and electrospun drug-loaded polymer fiber mats for dissolution enhancement

A comparative study

Attila Balogh, Balázs Farkas, Kornél Faragó, Attila Farkas, István Wagner, Ivo Van Assche, Geert Verreck, Zsombor K. Nagy, G. Marosi

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Melt blowing (MB) was investigated to prepare a fast dissolving fibrous drug-loaded solid dispersion and compared with solvent-based electrospinning (SES) and melt electrospinning (MES). As a conventional solvent-free technique coupled with melt extrusion and using a high-speed gas stream, MB can provide high-quality micro- and nanofibers at industrial throughput levels. Carvedilol, a weak-base model drug with poor water solubility, was processed using a common composition optimized for the fiber spinning and blowing methods based on a hydrophilic vinylpyrrolidone-vinyl acetate copolymer (PVPVA64) and PEG 3000 plasticizer. Scanning electron microscopy combined with fiber diameter analysis showed diameter distributions characteristic to each prepared fibrous fabrics (the mean value increased toward SES

Original languageEnglish
Pages (from-to)1767-1776
Number of pages10
JournalJournal of Pharmaceutical Sciences
Volume104
Issue number5
DOIs
Publication statusPublished - 2015

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Polymers
Pharmaceutical Preparations
Nanofibers
Plasticizers
Electron Scanning Microscopy
Solubility
Gases
Water
vinyl acetate
carvedilol

Keywords

  • Continuous pharmaceutical manufacturing
  • Electrospinning
  • Enhanced dissolution rate
  • Extrusion
  • HPLC
  • Melt blowing
  • Melt electrospinning
  • Oral drug delivery
  • Solid dispersion
  • Viscosity

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Melt-blown and electrospun drug-loaded polymer fiber mats for dissolution enhancement : A comparative study. / Balogh, Attila; Farkas, Balázs; Faragó, Kornél; Farkas, Attila; Wagner, István; Van Assche, Ivo; Verreck, Geert; Nagy, Zsombor K.; Marosi, G.

In: Journal of Pharmaceutical Sciences, Vol. 104, No. 5, 2015, p. 1767-1776.

Research output: Contribution to journalArticle

Balogh, A, Farkas, B, Faragó, K, Farkas, A, Wagner, I, Van Assche, I, Verreck, G, Nagy, ZK & Marosi, G 2015, 'Melt-blown and electrospun drug-loaded polymer fiber mats for dissolution enhancement: A comparative study', Journal of Pharmaceutical Sciences, vol. 104, no. 5, pp. 1767-1776. https://doi.org/10.1002/jps.24399
Balogh, Attila ; Farkas, Balázs ; Faragó, Kornél ; Farkas, Attila ; Wagner, István ; Van Assche, Ivo ; Verreck, Geert ; Nagy, Zsombor K. ; Marosi, G. / Melt-blown and electrospun drug-loaded polymer fiber mats for dissolution enhancement : A comparative study. In: Journal of Pharmaceutical Sciences. 2015 ; Vol. 104, No. 5. pp. 1767-1776.
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