Melanin-related biochemistry of IGR 1 human melanoma cells

E. Karg, G. Odh, E. Rosengren, A. Wittbjer, H. Rorsman

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Cultured melanoma cells have been of great value in the study of pigment metabolism. IGR 1 human melanoma cells, established by Dr Christian Aubert, produce melanin in large quantities. These cells have been used for isolation of human tyrosinase which enzyme has not previously been obtained in a pure form. IGR 1 cells contain large amounts of 5-S-cysteinyl-dopa which is the quantitatively most important catecholic amino acid. This review deals with the metabolism of dopa, cysteinyldopa, glutathionyldopa, cysteine and glutathione, compounds of central importance in pigment metabolism. The information available on tyrosinase, catecholic compounds and on thiols in IGR 1 melanoma cells makes these cells most suitable for further investigation of the metabolism of human melanoma cells.

Original languageEnglish
Pages (from-to)5-13
Number of pages9
JournalMelanoma Research
Volume1
Issue number1
Publication statusPublished - 1991

Fingerprint

Melanins
Biochemistry
Melanoma
Dihydroxyphenylalanine
Monophenol Monooxygenase
Cysteinyldopa
Sulfhydryl Compounds
Glutathione
Cysteine
Cultured Cells
Amino Acids
Enzymes

Keywords

  • 5-S-cysteinyldopa
  • Cysteine
  • Dopa
  • Glutathione
  • Tyrosinase

ASJC Scopus subject areas

  • Cancer Research
  • Dermatology
  • Oncology

Cite this

Karg, E., Odh, G., Rosengren, E., Wittbjer, A., & Rorsman, H. (1991). Melanin-related biochemistry of IGR 1 human melanoma cells. Melanoma Research, 1(1), 5-13.

Melanin-related biochemistry of IGR 1 human melanoma cells. / Karg, E.; Odh, G.; Rosengren, E.; Wittbjer, A.; Rorsman, H.

In: Melanoma Research, Vol. 1, No. 1, 1991, p. 5-13.

Research output: Contribution to journalArticle

Karg, E, Odh, G, Rosengren, E, Wittbjer, A & Rorsman, H 1991, 'Melanin-related biochemistry of IGR 1 human melanoma cells', Melanoma Research, vol. 1, no. 1, pp. 5-13.
Karg E, Odh G, Rosengren E, Wittbjer A, Rorsman H. Melanin-related biochemistry of IGR 1 human melanoma cells. Melanoma Research. 1991;1(1):5-13.
Karg, E. ; Odh, G. ; Rosengren, E. ; Wittbjer, A. ; Rorsman, H. / Melanin-related biochemistry of IGR 1 human melanoma cells. In: Melanoma Research. 1991 ; Vol. 1, No. 1. pp. 5-13.
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