Medium-mediated transmission of insulin imprinting from Tetrahymena to mammalian (Chang-liver) cells

G. Csaba, P. Kovacs, O. Torok

Research output: Contribution to journalArticle


The fluid phase of Tetrahymena cultures treated and not treated with insulin for 1 h stimulated the insulin binding of Chang liver cells to a similar degree as plain yeast extract containing Bacto tryptone medium. The fluid phase of mixed (1:1) cultures of insulin-imprinted and virgin Tetrahymena cells accounted for a significant increase in insulin binding relative to all other systems, and also to that of Chang liver cell cultures directly imprinted with insulin. It appears that the cell-cell transmission of hormonal information in Tetrahymena cultures is associated with release into the nutrient medium of a factor, which is able to transmit the information pertaining to imprinting to mammalian cells.

Original languageEnglish
Pages (from-to)31-35
Number of pages5
JournalMicrobios Letters
Issue number169
Publication statusPublished - Sep 26 1990


ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Hematology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

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