Medium Isotope Effect in [3H]Diazepam Binding to Benzodiazepine Receptors of Synaptic Membranes

J. Kardos, I. Kovács, M. Simonyi

Research output: Contribution to journalArticle

Abstract

Abstract: Replacement of H2O by D2O resulted in significantly higher amount of [3H]diazepam specifically bound to synaptic membranes. The isotope effect arises from increased number of binding sites in D2O and is associated with a stronger solvation of membrane receptors by heavy water.

Original languageEnglish
Pages (from-to)644-646
Number of pages3
JournalJournal of neurochemistry
Volume45
Issue number2
DOIs
Publication statusPublished - Aug 1985

Keywords

  • DO
  • Isotope effect
  • Synaptic membrane receptors
  • [H]Diazepam binding

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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