Medicinal chemistry of antiviral/anticancer prodrugs subjected to phosphate conjugation

H. Kalász, A. Adem, M. Y. Hasan, E. Adeghate, N. Ram, Z. Gulyás, K. Tekes

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Certain xenobiotics are given in the "prodrug" form. Either the human body, or one compartment of the body, or the targeted virus itself metabolizes the prodrug into its active form. The bioprecursor form of drugs is used for a wide variety of reasons, namely: to make drug penetration into the target organ (mainly to the brain through the blood-brain- barrier) possible, eliminate unpleasant taste, alter (either increasing or decreasing) the half life of the active component or supply more than one active components to the body.

Original languageEnglish
Pages (from-to)822-845
Number of pages24
JournalMini-Reviews in Medicinal Chemistry
Volume10
Issue number9
DOIs
Publication statusPublished - 2010

Fingerprint

Pharmaceutical Chemistry
Prodrugs
Antiviral Agents
Phosphates
Xenobiotics
Blood-Brain Barrier
Human Body
Pharmaceutical Preparations
Half-Life
Viruses
Brain

Keywords

  • Anticancer
  • Antiviral
  • Bioprecursor
  • Conjugation
  • Medicinal chemistry
  • Phosphate
  • Prodrug

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Medicine(all)

Cite this

Medicinal chemistry of antiviral/anticancer prodrugs subjected to phosphate conjugation. / Kalász, H.; Adem, A.; Hasan, M. Y.; Adeghate, E.; Ram, N.; Gulyás, Z.; Tekes, K.

In: Mini-Reviews in Medicinal Chemistry, Vol. 10, No. 9, 2010, p. 822-845.

Research output: Contribution to journalArticle

Kalász, H. ; Adem, A. ; Hasan, M. Y. ; Adeghate, E. ; Ram, N. ; Gulyás, Z. ; Tekes, K. / Medicinal chemistry of antiviral/anticancer prodrugs subjected to phosphate conjugation. In: Mini-Reviews in Medicinal Chemistry. 2010 ; Vol. 10, No. 9. pp. 822-845.
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