Medicinal chemistry of antimigraine drugs

K. Tekes, P. Szegi, F. Hashemi, R. Laufer, H. Kalász, A. Siddiq, C. Ertsey

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Migraine is one of the most frequent neurological disorder with high impact on the quality of life. Primary headaches such as migraine are pathophysiologically complex disorders. The concept of the trigeminovascular system dysfunction in migraine has led to a number of drug discoveries dramatically changing the treatment options. Acute and prophylactic therapy targeting either the trigeminovascular system or central structures involve several groups of drugs with peculiar medicinal chemistry. In the proposed review up to date concept of treatment strategy, medicinal chemistry data of the drugs used will be summarized. The present review gives detailed information on drugs effective in aborting migraine attacks (by inhibiting prostanoid synthesis, are agonists of serotonin 5-HT1B/D receptors, on the recently introduced CGRP-receptor antagonists) and the drugs recommended for prophylactic treatment (selected beta-adrenergic receptor antagonists, Ca-channel inhibitors, antiepileptics, antidepressants). The pharmacokinetics, fate in the body (absorption, distribution, metabolism, excretion) and significant pharmacological effects as well as the recent bioanalytical methods for their determination are presented.

Original languageEnglish
Pages (from-to)3300-3316
Number of pages17
JournalCurrent medicinal chemistry
Volume20
Issue number26
DOIs
Publication statusPublished - Sep 1 2013

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Keywords

  • Migraine treatment
  • Pharmacodynamics
  • Pharmacokinetics

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

Cite this

Tekes, K., Szegi, P., Hashemi, F., Laufer, R., Kalász, H., Siddiq, A., & Ertsey, C. (2013). Medicinal chemistry of antimigraine drugs. Current medicinal chemistry, 20(26), 3300-3316. https://doi.org/10.2174/0929867311320260012