Medicated straws based on electrospun solid dispersions

Balázs Farkas, Attila Balogh, Attila Farkas, András Domokos, Enikő Borbás, G. Marosi, Zsombor Kristóf Nagy

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Novel medicated straws were developed based on drug-loaded electrospun fibers prepared by direct current electrospinning (DCES) and high-speed electrospinning (HSES) of scaled-up productivity. Good quality micro- and nanofibers were electrospun using both techniques despite the multiple times higher throughput rate of HSES based on the scanning electron microscopic imaging (SEM). Solid state analyses revealed that the poorly soluble model drug carvedilol (CAR) was dispersed in an amorphous form in the electrospun polyvinylpyrrolidone (PVPK30) fibers. In vitro dissolution studies revealed ultrafast drug release from the prepared fibrous formulations inserted into plastic straws. Based on the results the developed drug delivery system is suitable for storing the formulation in a solid dosage form and in situ turning it into liquid form when administered.

Original languageEnglish
Pages (from-to)310-316
Number of pages7
JournalPeriodica Polytechnica Chemical Engineering
Volume62
Issue number3
DOIs
Publication statusPublished - May 16 2018

Fingerprint

Straw
Electrospinning
Dispersions
Pharmaceutical Preparations
Povidone
Fibers
Dosage Forms
Nanofibers
Dissolution
Productivity
Throughput
Plastics
Scanning
Imaging techniques
Electrons
Liquids

Keywords

  • Amorphous solid dispersions
  • High speed electrospinning
  • Medicated straws
  • Novel drug delivery system

ASJC Scopus subject areas

  • Chemical Engineering(all)

Cite this

Farkas, B., Balogh, A., Farkas, A., Domokos, A., Borbás, E., Marosi, G., & Nagy, Z. K. (2018). Medicated straws based on electrospun solid dispersions. Periodica Polytechnica Chemical Engineering, 62(3), 310-316. https://doi.org/10.3311/PPch.11931

Medicated straws based on electrospun solid dispersions. / Farkas, Balázs; Balogh, Attila; Farkas, Attila; Domokos, András; Borbás, Enikő; Marosi, G.; Nagy, Zsombor Kristóf.

In: Periodica Polytechnica Chemical Engineering, Vol. 62, No. 3, 16.05.2018, p. 310-316.

Research output: Contribution to journalArticle

Farkas, B, Balogh, A, Farkas, A, Domokos, A, Borbás, E, Marosi, G & Nagy, ZK 2018, 'Medicated straws based on electrospun solid dispersions', Periodica Polytechnica Chemical Engineering, vol. 62, no. 3, pp. 310-316. https://doi.org/10.3311/PPch.11931
Farkas, Balázs ; Balogh, Attila ; Farkas, Attila ; Domokos, András ; Borbás, Enikő ; Marosi, G. ; Nagy, Zsombor Kristóf. / Medicated straws based on electrospun solid dispersions. In: Periodica Polytechnica Chemical Engineering. 2018 ; Vol. 62, No. 3. pp. 310-316.
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