Kis GTP-kötö fehérjék orvosi jelentösége.

Translated title of the contribution: Medical importance of GTP-binding proteins

Research output: Contribution to journalArticle

Abstract

Small GTP-binding proteins consist of one single, 21 kD polypeptide chain. These regulatory proteins are active in the GTP-bound but inactive in the GDP-bound form. They are involved in the regulation of several important cell functions, such as cell division, cell motility, shape changes, intracellular membrane traffic, transport of macromolecules between cytoplasm and nucleus, assembly of enzyme complexes. Recently several mutations have been described which modify the function of small G-proteins resulting in typical pathological changes. These diseases and the molecular alterations involved in their pathomechanism are summarized in this review.

Original languageHungarian
Pages (from-to)2385-2391
Number of pages7
JournalOrvosi Hetilap
Volume140
Issue number43
Publication statusPublished - Oct 24 1999

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Intracellular Membranes
Monomeric GTP-Binding Proteins
Cell Shape
Guanosine Triphosphate
GTP-Binding Proteins
Cell Division
Cell Movement
Cytoplasm
Peptides
Mutation
Enzymes
Proteins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kis GTP-kötö fehérjék orvosi jelentösége. / Ligeti, E.; Geiszt, M.

In: Orvosi Hetilap, Vol. 140, No. 43, 24.10.1999, p. 2385-2391.

Research output: Contribution to journalArticle

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