Mediators of Angiogenesis: The Role of Cellular Adhesion Molecules

Zoltan Szekanecz, Margaret M. Halloran, Catherine J. Haskell, Manisha R. Shah, Peter J. Polverini, Alisa E. Koch

Research output: Contribution to journalShort survey

10 Citations (Scopus)


Angiogenesis, the production of new blood vessels, plays an important role in a number of physiological and pathological processes, such as development, tissue repair, inflammation, atherosclerosis and tumor progression. A number of mediators including cytokines, growth factors and others, have been implicated in angiogenesis. During tissue neovascularization, endothelial cells (EC) adhere to extracellular matrix (ECM) components and other ECs, which is an essential process in angiogenesis. Thus, in addition to soluble mediators mentioned above, ECM macromolecules and cellular adhesion molecules (CAMs) may also act as angiogenic factors. Among CAMs, E-selectin, vascular cell adhesion molecule (VCAM)-1, CD31, and some integrins may facilitate capillary formation both in vivo and in vitro. CAMs, as well as other angiogenic mediators may play a role in the pathogenesis of "angiogenic diseases". Targeting of any of these factors may have potential therapeutic relevance in such disorders.

Original languageEnglish
Pages (from-to)73-93
Number of pages21
JournalTrends in Glycoscience and Glycotechnology
Issue number58
Publication statusPublished - Mar 1999



  • Angiogenesis
  • Angiogenic factors
  • Cellular adhesion molecules
  • Extracellular matrix
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

Cite this

Szekanecz, Z., Halloran, M. M., Haskell, C. J., Shah, M. R., Polverini, P. J., & Koch, A. E. (1999). Mediators of Angiogenesis: The Role of Cellular Adhesion Molecules. Trends in Glycoscience and Glycotechnology, 11(58), 73-93.