Mediators involved in the hyperthermic action of neuromedin U in rats

G. Telegdy, A. Adamik

Research output: Contribution to journalArticle

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Abstract

Neuromedin U (NmU), first was isolated from the porcine spinal cord, has subsequently been demonstrated in a number of species, in which it is present in the periphery and also the brain. Two receptors have been identified: NmU1R is mainly present in peripheral tissues, and Nmu2R in the central nervous system. NmU, a potent endogenous anorectic, serves as a catabolic signaling molecule in the brain; it inhibits food uptake, increases locomotion, activates stress mechanism, having cardiovasscular effects and, causes hyperthermia. The mechanism of this hyperthermia is unknown. In the present experiments, the effects of NmU on the colon temperature following i.c.v administration were studied in rats. For an investigation of the possible role of receptors in mediating hyperthermia, the animals were treated simultaneously with CRF 9-41 and antalarmin, a CRH1 receptor inhibitors, astressin 2B, a CRH2 receptor antagonist, haloperidol a dopamine receptor antagonist, atropine a muscarinic cholinergic receptor antagonist, noraminophenazone a cyclooxygenase inhibitor or isatin, a prostaglandin receptor antagonist.NmU increased the colon temperature, maximal action being observed at 2-3. h. CRF 9-41, antalarmin, astressin 2B haloperidol, atropine, noraminophenazone and isatin prevented the NmU-induced increase in colon temperature.The results demonstrated that, when injected into the lateral brain ventricle NmU increased the body temperature, mediated by CRHR1 and CRHR2, dopamine and muscarinic cholinergic receptors. The final pathway involves prostaglandin.

Original languageEnglish
Pages (from-to)24-29
Number of pages6
JournalRegulatory Peptides
Volume192-193
DOIs
Publication statusPublished - 2014

Fingerprint

Rats
Isatin
Brain
Colon
Fever
Muscarinic Receptors
Haloperidol
Atropine
Cholinergic Agents
Temperature
Prostaglandin Receptors
Prostaglandin Antagonists
Appetite Depressants
Cyclooxygenase Inhibitors
Dopamine Antagonists
Lateral Ventricles
Cholinergic Antagonists
Neurology
Cholinergic Receptors
Locomotion

Keywords

  • Hyperthermia
  • Neuromedin U
  • Receptors

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience
  • Medicine(all)

Cite this

Mediators involved in the hyperthermic action of neuromedin U in rats. / Telegdy, G.; Adamik, A.

In: Regulatory Peptides, Vol. 192-193, 2014, p. 24-29.

Research output: Contribution to journalArticle

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