Mechanisms responsible for increased vascular permeability, fibrin deposits and chemotaxis in delayed hypersensitivity reactions

S. Sipka, T. Szilagyi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Plasmin is proposed to have a central regulating role because it can be produced by lymphokine-activated macrophages, by activated Factor XII and probably by lymphokines. Thus, plasmin itself can cotinue activating Factor XII and result in the production of fibrin deposits and kinins in delayed inflammation. In accepting the data that bradykinin is able to liberate prostaglandins, prostaglandins can decrease the production of lymphokines, a self regulating cycle can be constructed for the process of delayed hypersensitivity reactions mediated by lymphokines. In this short review a scheme is presented as a possible explanation of the mechanism responsible for increased vascular permeability, fibrin deposits and chemotaxis in delayed hypersensitivity reactions.

Original languageEnglish
Pages (from-to)469-470
Number of pages2
JournalBritish Journal of Dermatology
Volume97
Issue number4
Publication statusPublished - 1977

Fingerprint

Lymphokines
Delayed Hypersensitivity
Capillary Permeability
Chemotaxis
Fibrin
Fibrinolysin
Prostaglandins
Factor XIIa
Factor XII
Kinins
Bradykinin
Macrophages
Inflammation

ASJC Scopus subject areas

  • Dermatology

Cite this

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