Mechanisms of multidrug resistance in Acinetobacter species and Pseudomonas aeruginosa

Robert A. Bonomo, Dora Szabo

Research output: Contribution to journalArticle

439 Citations (Scopus)

Abstract

Acinetobacter species and Pseudomonas aeruginosa are noted for their intrinsic resistance to antibiotics and for their ability to acquire genes encoding resistance determinants. Foremost among the mechanisms of resistance in both of these pathogens is the production of β-lactamases and aminoglycoside-modifying enzymes. Additionally, diminished expression of outer membrane proteins, mutations in topoisomerases, and up-regulation of efflux pumps play an important part in antibiotic resistance. Unfortunately, the accumulation of multiple mechanisms of resistance leads to the development of multiply resistant or even "panresistant" strains.

Original languageEnglish
Pages (from-to)S49-S56
JournalClinical Infectious Diseases
Volume43
Issue numberSUPPL. 2
DOIs
Publication statusPublished - Sep 1 2006

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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