Mechanisms of multidrug resistance in Acinetobacter species and Pseudomonas aeruginosa

Robert A. Bonomo, D. Szabó

Research output: Contribution to journalArticle

427 Citations (Scopus)

Abstract

Acinetobacter species and Pseudomonas aeruginosa are noted for their intrinsic resistance to antibiotics and for their ability to acquire genes encoding resistance determinants. Foremost among the mechanisms of resistance in both of these pathogens is the production of β-lactamases and aminoglycoside-modifying enzymes. Additionally, diminished expression of outer membrane proteins, mutations in topoisomerases, and up-regulation of efflux pumps play an important part in antibiotic resistance. Unfortunately, the accumulation of multiple mechanisms of resistance leads to the development of multiply resistant or even "panresistant" strains.

Original languageEnglish
JournalClinical Infectious Diseases
Volume43
Issue numberSUPPL. 2
DOIs
Publication statusPublished - Sep 1 2006

Fingerprint

Acinetobacter
Multiple Drug Resistance
Microbial Drug Resistance
Pseudomonas aeruginosa
Aminoglycosides
Membrane Proteins
Up-Regulation
Mutation
Enzymes
Genes

ASJC Scopus subject areas

  • Immunology

Cite this

Mechanisms of multidrug resistance in Acinetobacter species and Pseudomonas aeruginosa. / Bonomo, Robert A.; Szabó, D.

In: Clinical Infectious Diseases, Vol. 43, No. SUPPL. 2, 01.09.2006.

Research output: Contribution to journalArticle

@article{58f563fed29d4305ac76cc73a32b307e,
title = "Mechanisms of multidrug resistance in Acinetobacter species and Pseudomonas aeruginosa",
abstract = "Acinetobacter species and Pseudomonas aeruginosa are noted for their intrinsic resistance to antibiotics and for their ability to acquire genes encoding resistance determinants. Foremost among the mechanisms of resistance in both of these pathogens is the production of β-lactamases and aminoglycoside-modifying enzymes. Additionally, diminished expression of outer membrane proteins, mutations in topoisomerases, and up-regulation of efflux pumps play an important part in antibiotic resistance. Unfortunately, the accumulation of multiple mechanisms of resistance leads to the development of multiply resistant or even {"}panresistant{"} strains.",
author = "Bonomo, {Robert A.} and D. Szab{\'o}",
year = "2006",
month = "9",
day = "1",
doi = "10.1086/504477",
language = "English",
volume = "43",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "Oxford University Press",
number = "SUPPL. 2",

}

TY - JOUR

T1 - Mechanisms of multidrug resistance in Acinetobacter species and Pseudomonas aeruginosa

AU - Bonomo, Robert A.

AU - Szabó, D.

PY - 2006/9/1

Y1 - 2006/9/1

N2 - Acinetobacter species and Pseudomonas aeruginosa are noted for their intrinsic resistance to antibiotics and for their ability to acquire genes encoding resistance determinants. Foremost among the mechanisms of resistance in both of these pathogens is the production of β-lactamases and aminoglycoside-modifying enzymes. Additionally, diminished expression of outer membrane proteins, mutations in topoisomerases, and up-regulation of efflux pumps play an important part in antibiotic resistance. Unfortunately, the accumulation of multiple mechanisms of resistance leads to the development of multiply resistant or even "panresistant" strains.

AB - Acinetobacter species and Pseudomonas aeruginosa are noted for their intrinsic resistance to antibiotics and for their ability to acquire genes encoding resistance determinants. Foremost among the mechanisms of resistance in both of these pathogens is the production of β-lactamases and aminoglycoside-modifying enzymes. Additionally, diminished expression of outer membrane proteins, mutations in topoisomerases, and up-regulation of efflux pumps play an important part in antibiotic resistance. Unfortunately, the accumulation of multiple mechanisms of resistance leads to the development of multiply resistant or even "panresistant" strains.

UR - http://www.scopus.com/inward/record.url?scp=33747625237&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33747625237&partnerID=8YFLogxK

U2 - 10.1086/504477

DO - 10.1086/504477

M3 - Article

C2 - 16894515

AN - SCOPUS:33747625237

VL - 43

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

SN - 1058-4838

IS - SUPPL. 2

ER -