Heme oxygenases (HO) catabolize free heme, that is, iron (Fe) protoporphyrin (IX), into equimolar amounts of Fe2+, carbon monoxide (CO), and biliverdin. The stress-responsive HO-1 isoenzyme affords protection against programmed cell death. The mechanism underlying this cytoprotective effect relies on the ability of HO-1 to catabolize free heme and prevent it from sensitizing cells to undergo programmed cell death. This cytoprotective effect inhibits the pathogenesis of a variety of immune-mediated inflammatory diseases.
|Number of pages||32|
|Journal||Annual Review of Pharmacology and Toxicology|
|Publication status||Published - Feb 10 2010|
- Cell death
- Free radicals
- Immune-mediated inflammatory diseases
ASJC Scopus subject areas