Mechanisms of antimotility action of tricyclic compounds in Proteus vulgaris.

J. K. Ren, S. Petöfi, J. Molnár

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Tricyclic compounds were able to inhibit the motility of Proteus vulgaris. The effectiveness of antimotility action was related to the physicochemical properties of the molecules, i.e. energy of HOMO, Log P, total surface. The antimotility action of the compounds was due to their reversible inhibition on the proton pump of the bacterium. Phosphate anion antagonized the antimotility, and potassium cation enhanced the action of phosphate anion on the antimotility effect induced by the agents. Glucose reversed the antimotility action of the compounds. Factors directly increasing the bacterial proton-motive force (PMF) could change bacterial motility and the antimotility action of the tricyclic compounds.

Original languageEnglish
Pages (from-to)369-377
Number of pages9
JournalActa Microbiologica Hungarica
Volume40
Issue number4
Publication statusPublished - 1993

Fingerprint

Proteus vulgaris
Anions
Phosphates
Proton Pumps
Proton-Motive Force
Cations
Potassium
Bacteria
Glucose

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

Cite this

Mechanisms of antimotility action of tricyclic compounds in Proteus vulgaris. / Ren, J. K.; Petöfi, S.; Molnár, J.

In: Acta Microbiologica Hungarica, Vol. 40, No. 4, 1993, p. 369-377.

Research output: Contribution to journalArticle

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