Mechanisms involved in the cerebrovascular dilator effects of N-methyl-d-aspartate in cerebral cortex

David W. Busija, F. Bari, F. Domoki, Thomas Louis

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Glutamate and its synthetic analogues N-methyl-d-aspartate (NMDA), kainate, and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) are potent dilator agents in the cerebral circulation. The close linkage between neural activity-based release and actions of glutamate on neurons and the related decrease in cerebral vascular resistance is a classic example in support of the concept of tight coupling between increased neural activity and cerebral blood flow. However, mechanisms involved in promoting cerebral vasodilator responses to glutamatergic agents are controversial. Here we review the development and current status of this important field of research especially in respect to cerebrovascular responses to NMDA receptor activation.

Original languageEnglish
Pages (from-to)89-100
Number of pages12
JournalBrain Research Reviews
Volume56
Issue number1
DOIs
Publication statusPublished - Nov 2007

Fingerprint

Cerebrovascular Circulation
Aspartic Acid
Cerebral Cortex
Glutamic Acid
Excitatory Amino Acid Agents
Kainic Acid
Propionates
Vasodilator Agents
Vascular Resistance
Neurons
Research

Keywords

  • Cerebral arteries
  • Cerebral circulation
  • Glutamate
  • Ischemia
  • Neurons
  • Nitric oxide
  • NMDA receptor
  • Piglets
  • Rabbits
  • Rats

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Mechanisms involved in the cerebrovascular dilator effects of N-methyl-d-aspartate in cerebral cortex. / Busija, David W.; Bari, F.; Domoki, F.; Louis, Thomas.

In: Brain Research Reviews, Vol. 56, No. 1, 11.2007, p. 89-100.

Research output: Contribution to journalArticle

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