Mechanisms behind flare of renal lupus during murine pregnancy

Ana Claudia Zenclussen, Gábor Kökény, Odina Thimm, André Sollwedel, Maria Godo, Pablo Ariel Casalis, Maria Laura Zenclussen, Hans Dieter Volk, P. Hamar

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The outcome of pregnancy in systemic lupus erythematosus is still controversial. The authors recently reported the disappearance of the manifestation of the skin disease but a diminished survival rate in lupus-prone animals undergoing several pregnancies. It was postulated that lupus-prone animals must have subclinical renal symptoms at an early age and that immune and hormonal changes during pregnancy exacerbate immune reactions in the kidneys, leading to a shortened life span. Here, the authors analysed changes at day 14 of pregnancy in lupus-prone LPR (MRL/lpr) mice and MRL controls regarding cytokines, regulatory T (Treg) cells and deposition of immunocomplexes. Worsened kidney function was observed during pregnancy, even in the absence of lupus signs. This was accompanied by renal inflammation and higher interferon-γ and interleukin-10 levels. C3 and immunoglobulin G deposition was enhanced in kidney and placenta from lupus-prone pregnant animals. Pregnancy enhanced the levels of Treg cells in control animals but not in lupus-prone animals. As pregnancy-induced Treg cells were shown to be specific for paternal antigens it is not to be expected that these Treg cells can help to destroy autoreactive cells. The authors conclude that early subclinical kidney disease in lupus-prone animals exacerbates during pregnancy. Albeit obtained with an experimental animal model, their data are potentially of importance for lupus patients of reproductive age.

Original languageEnglish
Pages (from-to)114-126
Number of pages13
JournalReproductive BioMedicine Online
Volume17
Issue number1
Publication statusPublished - Jul 2008

Fingerprint

Regulatory T-Lymphocytes
Kidney
Pregnancy
Inbred MRL lpr Mouse
Kidney Diseases
Pregnancy Outcome
Skin Diseases
Systemic Lupus Erythematosus
Interleukin-10
Interferons
Placenta
Survival Rate
Animal Models
Immunoglobulin G
Cytokines
Inflammation
Antigens

Keywords

  • Autoimmunity
  • C3
  • Glomerulonephritis
  • IgG
  • Pregnancy
  • Treg

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Zenclussen, A. C., Kökény, G., Thimm, O., Sollwedel, A., Godo, M., Casalis, P. A., ... Hamar, P. (2008). Mechanisms behind flare of renal lupus during murine pregnancy. Reproductive BioMedicine Online, 17(1), 114-126.

Mechanisms behind flare of renal lupus during murine pregnancy. / Zenclussen, Ana Claudia; Kökény, Gábor; Thimm, Odina; Sollwedel, André; Godo, Maria; Casalis, Pablo Ariel; Zenclussen, Maria Laura; Volk, Hans Dieter; Hamar, P.

In: Reproductive BioMedicine Online, Vol. 17, No. 1, 07.2008, p. 114-126.

Research output: Contribution to journalArticle

Zenclussen, AC, Kökény, G, Thimm, O, Sollwedel, A, Godo, M, Casalis, PA, Zenclussen, ML, Volk, HD & Hamar, P 2008, 'Mechanisms behind flare of renal lupus during murine pregnancy', Reproductive BioMedicine Online, vol. 17, no. 1, pp. 114-126.
Zenclussen AC, Kökény G, Thimm O, Sollwedel A, Godo M, Casalis PA et al. Mechanisms behind flare of renal lupus during murine pregnancy. Reproductive BioMedicine Online. 2008 Jul;17(1):114-126.
Zenclussen, Ana Claudia ; Kökény, Gábor ; Thimm, Odina ; Sollwedel, André ; Godo, Maria ; Casalis, Pablo Ariel ; Zenclussen, Maria Laura ; Volk, Hans Dieter ; Hamar, P. / Mechanisms behind flare of renal lupus during murine pregnancy. In: Reproductive BioMedicine Online. 2008 ; Vol. 17, No. 1. pp. 114-126.
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