Mechanism of endothelin-induced malignant ventricular arrhythmias in dogs

B. Merkely, L. Gellér, Miklós Tóth, Orsolya Kiss, V. Kékesi, Francis Solti, Tibor Vecsey, F. Horkay, Joseph Tenczer, A. Juhász-Nagy

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The development of ventricular tachyarrhythmias caused by low-dose intracoronary infusion of endothelin-1 (ET-1) has recently been observed in dogs. The aim of the present study was to investigate the pathomechanism of ET-1-induced ventricular arrhythmias in 32 anesthetized, open-chest mongrel dogs in group A (n = 14) without, in group B (n = 14), and in group C (n = 4 control) with atrioventricular node ablation. The coronary blood flow (CBF) was measured in the left anterior descending (LAD) coronary artery by an electromagnetic flowmeter. Standard ECG, atrial and ventricular electrograms, and in groups B and C endocardial and epicardial monophasic action potentials (MAPs) were recorded. ET-1 was administered into the LAD at a low dose (30-60 pmol/min). At the time of the appearance of premature beats, CBF was only slightly decreased. The effective ventricular refractory period did not change significantly. Onset of spontaneous polymorphic and monomorphic sustained ventricular tachycardia (sVT) was observed in five dogs without bradycardia and in nine dogs with bradycardia. VTs in dogs with complete AV block were longer and slower. In most of the cases, ventricular fibrillation occurred. ET-1 treatment resulted in a significant increase in MAP 90% duration (255 ± 9 vs. 290 ± 8 ms endocardial, 244 ± 10 vs. 292 ± 12 epicardial; p <0.05) at 70 beats/min ventricular pacing. In eight cases (group B), third-phase early afterdepolarization could be recorded. According to our results, the mechanism of ET-1-induced arrhythmias appears to be based on prolongation of MAP duration and development of afterdepolarizations.

Original languageEnglish
JournalJournal of Cardiovascular Pharmacology
Volume31
Issue numberSUPPL. 1
Publication statusPublished - 1998

Fingerprint

Endothelins
Endothelin-1
Cardiac Arrhythmias
Dogs
Action Potentials
Bradycardia
Cardiac Electrophysiologic Techniques
Premature Cardiac Complexes
Flowmeters
Atrioventricular Node
Atrioventricular Block
Electromagnetic Phenomena
Ventricular Fibrillation
Ventricular Tachycardia
Tachycardia
Coronary Vessels
Electrocardiography
Thorax

Keywords

  • Endothelin-1
  • Monophasic action potential
  • Pathomechanism
  • Ventricular arrhythmias

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

Cite this

Mechanism of endothelin-induced malignant ventricular arrhythmias in dogs. / Merkely, B.; Gellér, L.; Tóth, Miklós; Kiss, Orsolya; Kékesi, V.; Solti, Francis; Vecsey, Tibor; Horkay, F.; Tenczer, Joseph; Juhász-Nagy, A.

In: Journal of Cardiovascular Pharmacology, Vol. 31, No. SUPPL. 1, 1998.

Research output: Contribution to journalArticle

Merkely, B. ; Gellér, L. ; Tóth, Miklós ; Kiss, Orsolya ; Kékesi, V. ; Solti, Francis ; Vecsey, Tibor ; Horkay, F. ; Tenczer, Joseph ; Juhász-Nagy, A. / Mechanism of endothelin-induced malignant ventricular arrhythmias in dogs. In: Journal of Cardiovascular Pharmacology. 1998 ; Vol. 31, No. SUPPL. 1.
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AU - Vecsey, Tibor

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