Mechanism of enantioseparation on zeolite-supported chiral stationary phases in the presence of lipophilic buffer

L. P. Szabó, K. Selmeczi, Z. Pilter, A. Szécsi, J. Bodnár, É H. Lippai, D. Kalló, L. Szotyory

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Chiral stationary phases have been prepared on a zeolite A support. In addition to polar hydrophilic chiral selector molecules derived from DNB-L-Leu and DNB-L-Phe amides, dynamic modification of the underivatized free surface hydroxyl (silanol) groups of the zeolite can be used to increase the overall hydrophobic character. On these non-capped chiral stationary phases, in the presence of lipophilic buffer salts in the aqueous organic phase, the enantioseparation of ion-paired D,L-mandelic acid was facilitated and was studied in more detail. The enantioseparation might be based on hydrogen bonding and π-π interaction supported by simultaneous hydrophobic interaction.

Original languageEnglish
Pages (from-to)140-144
Number of pages5
JournalChromatographia
Volume48
Issue number1-2
DOIs
Publication statusPublished - Jul 29 1998

Keywords

  • Chiral stationary phase (brush type)
  • Hydrophobic interaction
  • Ion-pairing
  • Lipophilic buffer
  • Zeolite support

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Clinical Biochemistry
  • Organic Chemistry

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    Szabó, L. P., Selmeczi, K., Pilter, Z., Szécsi, A., Bodnár, J., Lippai, É. H., Kalló, D., & Szotyory, L. (1998). Mechanism of enantioseparation on zeolite-supported chiral stationary phases in the presence of lipophilic buffer. Chromatographia, 48(1-2), 140-144. https://doi.org/10.1007/BF02467530