Mechanism of drug release from silica-gelatin aerogel—Relationship between matrix structure and release kinetics

Péter Veres, Mónika Kéri, István Bányai, István Lázár, I. Fábián, Concepción Domingo, József Kalmár

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Specific features of a silica-gelatin aerogel (3 wt.% gelatin content) in relation to drug delivery has been studied. It was confirmed that the release of both ibuprofen (IBU) and ketoprofen (KET) is about tenfold faster from loaded silica-gelatin aerogel than from pure silica aerogel, although the two matrices are structurally very similar. The main goal of the study was to understand the mechanistic background of the striking difference between the delivery properties of these closely related porous materials. Hydrated and dispersed silica-gelatin aerogel has been characterized by NMR cryoporometry, diffusiometry and relaxometry. The pore structure of the silica aerogel remains intact when it disintegrates in water. In contrast, dispersed silica-gelatin aerogel develops a strong hydration sphere, which reshapes the pore walls and deforms the pore structure. The drug release kinetics was studied on a few minutes time scale with 1 s time resolution. Simultaneous evaluation of all relevant kinetic and structural information confirmed that strong hydration of the silica-gelatin skeleton facilitates the rapid desorption and dissolution of the drugs from the loaded aerogel. Such a driving force is not operative in pure silica aerogels.

Original languageEnglish
Pages (from-to)229-237
Number of pages9
JournalColloids and Surfaces B: Biointerfaces
Volume152
DOIs
Publication statusPublished - Apr 1 2017

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Keywords

  • Aerogel structure
  • Drug release
  • Kinetics
  • NMR spectroscopy

ASJC Scopus subject areas

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

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