Mechanism of aminopyridine-induced ictal seizure activity in the cat neocortex

Magdolna Szente, Attila Baranyi

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Intracellular recordings were obtained from neurons in the motor cortex of anesthetized cats in order to examine membrane and synaptic processes involved in aminopyridine (AP)-induced ictal seizure activity. Depolarizing and hyperpolarizing membrane potential sequences which behaved as large, synchronized excitatory and inhibitory postsynaptic potentials, were found to accompany the ictal seizure potentials. After several repetitions of the seizure attack, partial responses, bursts and depolarizing plateaus with spike inactivation occurred. In layers IV and V we found non-pyramidal tract neurons showing endogenous bursting ability activated by AP. These neurons seemed to be the initiators of the rhythmic synchronous activity of the epileptic neuron population. Our results suggest, that AP-induced epileptogenesis represents an adequate model of ictal events in the neocortex.

Original languageEnglish
Pages (from-to)368-373
Number of pages6
JournalBrain research
Volume413
Issue number2
DOIs
Publication statusPublished - Jun 16 1987

Keywords

  • Aminopyridine
  • Bursting activity
  • Epilepsy
  • Giant PSP
  • Neocortex

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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