Mechanism of action of heparin through thrombin on blood coagulation

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Abstract

It has been suggested that heparin can affect blood coagulation through thrombin, i.e. the binding of heparin to thrombin induces a conformational change in the enzyme, facilitating a complex formation between thrombin and antithrombin (Machovich, R., Blaskó, Gy. and Pálos, L. (1975) Biochim. Biophys. Acta 379, 193-200). This hypothesis seems to have been proved. Modification of arginine residues in thrombin did not result in decreased thrombin activity and decreased sensitivity to antithrombin, whereas the heparin sensitivity of the enzyme and the thrombin-antithrombin reaction were diminished.

Original languageEnglish
Pages (from-to)13-17
Number of pages5
JournalBBA - Protein Structure
Volume412
Issue number1
DOIs
Publication statusPublished - Nov 18 1975

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Blood Coagulation
Coagulation
Thrombin
Heparin
Blood
Antithrombins
Enzymes
Arginine

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Mechanism of action of heparin through thrombin on blood coagulation. / Machovich, R.

In: BBA - Protein Structure, Vol. 412, No. 1, 18.11.1975, p. 13-17.

Research output: Contribution to journalArticle

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