Mechanism and dynamics of macroautophagy in murine exocrine pancreatic cells. A review of vinblastine-induced changes.

G. Réz, E. Fellinger, O. Oliva, Z. Pálfia, J. Csák, L. László, A. L. Kovács, J. Kovács, A. P. Kárpáti

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Autophagy is a major pathway of lysosomal degradation of cellular macromolecules. The paper summarizes the results obtained in the studies on macroautophagy using the exocrine pancreatic acinar cell as model system and vinblastine as inducer. Current knowledge about the origin and properties of the limiting membranes of autophagic vacuoles, and the results of quantitative morphological studies into the dynamics and kinetics of vinblastine-induced autophagocytosis, as well as recent achievements in isolation and characterization of subclasses of autophagic vacuoles (autophagosomes and autolysosomes) are reviewed.

Original languageEnglish
Pages (from-to)57-86
Number of pages30
JournalActa biologica Hungarica
Volume42
Issue number1-3
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Neurology

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