Mechanical stability and fibrinolytic resistance of clots containing fibrin, DNA, and histones

Colin Longstaff, Imre Varjú, Péter Sótonyi, László Szabó, Michael Krumrey, Armin Hoell, Attila Bóta, Zoltán Varga, Erzsébet Komorowicz, Krasimir Kolev

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Abstract

Background: Neutrophil extracellular traps (NETs) composed of DNA and proteins form a scaffold in thrombi, supplementing the fibrin matrix. Results: DNA and histones modify the structure of fibrin and render it resistant to mechanical and enzymatic destruction. Conclusion: NET components are essential factors in thrombus stability. Significance: Therapeutic strategies could be optimized to enhance fibrinolysis in clots containing DNA and histones.

Original languageEnglish
Pages (from-to)6946-6956
Number of pages11
JournalJournal of Biological Chemistry
Volume288
Issue number10
DOIs
Publication statusPublished - Mar 8 2013

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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