Authors evaluated prospectively the effect of extracorporeal shock wave lithotripsy (ESWL) on kidney function by measuring cystatin C as a new marker of glomerular filtration rate (GFR). Serum cystatin C was determined before and after ESWL treatment for 50 patients with unilateral renal stone. To eliminate the compensatory effects of an untreated contra lateral kidney, cystatin C was measured for 16 patients treated due to stone in their solitary kidney as well. Statistical data analysis was performed with SigmaStat 3.0: using paired t-test in bilateral kidney group (p<0.05 was considered as clinically significant) and Wilcoxon Rank Sum Test in solitary kidney group (p<0,05 was considered as clinically significant change). The serum cystatin C increased in 30 (60%) patients, decreased in 14 (28%) patients and remained unchanged in 6 (12%) patients on patients with bilateral kidneys, while increased in 8 (50%) patients and decreased in 8 (50%) patients on patients with solitary kidneys. The change in bilateral kidney group was clinically significant (p=0,036, performed test power=0,598), while the change in solitary kidney group was not clinically significant (p=0.19). On the basis of our series it can be concluded that there was evidence that ESWL resulted in the deterioration of renal function at early post-treatment follow up in patients with bilateral kidneys, while no significance change was noticed in patients with solitary kidneys.
|Number of pages||5|
|Publication status||Published - Dec 1 2005|
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