Measuring lung function in murine models of pulmonary disease

Peter D. Sly, Debra J. Turner, Zoltan Hantos

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Mice are commonly used to model human lung diseases. However, their small size poses substantial problems for accurately measuring lung function. Noninvasive techniques have been widely used but have severe limitations and should be restricted to screening for the presence of disease. Accurate measures of lung function and assessment of the site of disease pathology and drug action are possible using invasive techniques. Investigators must understand the strengths and weaknesses of each technique before deciding which to use.

Original languageEnglish
Pages (from-to)337-343
Number of pages7
JournalDrug Discovery Today: Disease Models
Volume1
Issue number3
DOIs
Publication statusPublished - Dec 17 2004

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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