Measurement of the disaggregating effect of prostacyclin (PGI2) in anaesthetized dogs

F. Herman, P. Hadhazy, K. Magyar

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The disaggregating effect of PGI2 was measured in a modified in vivo model first described by Hornstra. The arterial blood of mongrel dogs was directed through an extracorporeal filter by a roller pump, and the pressure before the filter was measured. The filter becomes spontaneously occluded within a few minutes, and as a result the pressure before the filter increases continuously. PGI2 administered before the filter or intravenously produced a dose-related reduction in filtration pressure. This simple technique seems to be useful for determining the disaggregatory effects of prostacyclin and other substances.

Original languageEnglish
Pages (from-to)S377-S380
JournalBiomedica Biochimica Acta
Issue number8-9
Publication statusPublished - Dec 1 1984


ASJC Scopus subject areas

  • Biochemistry

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