The disaggregating effect of PGI2 was measured in a modified in vivo model first described by Hornstra. The arterial blood of mongrel dogs was directed through an extracorporeal filter by a roller pump, and the pressure before the filter was measured. The filter becomes spontaneously occluded within a few minutes, and as a result the pressure before the filter increases continuously. PGI2 administered before the filter or intravenously produced a dose-related reduction in filtration pressure. This simple technique seems to be useful for determining the disaggregatory effects of prostacyclin and other substances.
|Journal||Biomedica Biochimica Acta|
|Publication status||Published - Dec 1 1984|
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