Measurement of the disaggregating effect of prostacyclin (PGI2) in anaesthetized dogs

F. Herman, P. Hadhazy, K. Magyar

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The disaggregating effect of PGI2 was measured in a modified in vivo model first described by Hornstra. The arterial blood of mongrel dogs was directed through an extracorporeal filter by a roller pump, and the pressure before the filter was measured. The filter becomes spontaneously occluded within a few minutes, and as a result the pressure before the filter increases continuously. PGI2 administered before the filter or intravenously produced a dose-related reduction in filtration pressure. This simple technique seems to be useful for determining the disaggregatory effects of prostacyclin and other substances.

Original languageEnglish
JournalBiomedica Biochimica Acta
Volume43
Issue number8-9
Publication statusPublished - 1984

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Epoprostenol
Dogs
Pressure
Blood
Pumps

ASJC Scopus subject areas

  • Biochemistry

Cite this

Measurement of the disaggregating effect of prostacyclin (PGI2) in anaesthetized dogs. / Herman, F.; Hadhazy, P.; Magyar, K.

In: Biomedica Biochimica Acta, Vol. 43, No. 8-9, 1984.

Research output: Contribution to journalArticle

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