Measurement of interleukin-1 receptor antagonist in patients with systemic lupus erythematosus could predict renal manifestation of the disease

Boglarka Brugos, E. Kiss, Csaba Dul, Wolfgang Gubisch, G. Szegedi, S. Sipka, M. Zeher

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Interleukin-1 receptor antagonist (IL-1Ra) is a good indicator of disease activity in patients with systemic lupus erythematosus (SLE). Glucocorticosteroids are the most frequently used drugs in SLE. Our goal was to compare IL-1Ra activity in SLE patients with and without renal involvement and to determine the effect of different dosage of glucocorticosteroids used in 17 patients with active SLE without nephritis, 7 patients with inactive lupus nephritis (LN), and 8 patients with active LN, along with 10 healthy controls. IL-1Ra levels were measured in the serum of SLE patients by Human Luminex [100] analyzer. Both in patients with active SLE without nephritis and in patients with LN, serum levels of IL-1Ra (p

Original languageEnglish
Pages (from-to)874-877
Number of pages4
JournalHuman Immunology
Volume71
Issue number9
DOIs
Publication statusPublished - Sep 2010

Fingerprint

Interleukin-1 Receptors
Systemic Lupus Erythematosus
Kidney
Lupus Nephritis
Nephritis
Serum
Pharmaceutical Preparations

Keywords

  • Active SLE
  • Creatinine clearance
  • Interleukin-1 receptor antagonist
  • Lupus nephritis
  • Methylprednisolone

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Measurement of interleukin-1 receptor antagonist in patients with systemic lupus erythematosus could predict renal manifestation of the disease. / Brugos, Boglarka; Kiss, E.; Dul, Csaba; Gubisch, Wolfgang; Szegedi, G.; Sipka, S.; Zeher, M.

In: Human Immunology, Vol. 71, No. 9, 09.2010, p. 874-877.

Research output: Contribution to journalArticle

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AU - Zeher, M.

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