Mean corpuscular volume is not a reliable marker of red cell age in case of anisocytosis

A. Kocsis, É Biró, É Rácz, A. Kiss, J. Kappelmayer

Research output: Contribution to journalArticle

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Abstract

The present study was designed to determine the effect of anisocytosis on the association of MCV values with HbA(1c) and reticulocyte counts as markers of red cell age. Normo-, micro- and macrocytic samples, fractionated by counterflow centrifugal elutriation were studied. The previously described correlation between MCV and HbA(1c) was only observed in normal samples and in the middle fractions of samples with anisocytosis. At both extremes of the elutriation profile, curves for HbA(1c) content and reticulocyte count levelled out. Furthermore, in fractions containing the largest red cells of the microcytic series and the smallest red cells of normo- and macrocytic samples, reticulocyte count decreased while HbA(1c) content increased with increasing MCV. From these data it is concluded that MCV is not an absolute determinant of red cell age in case of anisocytosis.

Original languageEnglish
Pages (from-to)149-151
Number of pages3
JournalAnnals of Hematology
Volume77
Issue number4
DOIs
Publication statusPublished - Oct 1998

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Erythrocyte Indices
Reticulocyte Count

Keywords

  • Centrifugal elutriation
  • Glycosylated hemoglobin
  • Mean corpuscular volume
  • Red cell age
  • Reticulocyte count

ASJC Scopus subject areas

  • Hematology

Cite this

Mean corpuscular volume is not a reliable marker of red cell age in case of anisocytosis. / Kocsis, A.; Biró, É; Rácz, É; Kiss, A.; Kappelmayer, J.

In: Annals of Hematology, Vol. 77, No. 4, 10.1998, p. 149-151.

Research output: Contribution to journalArticle

Kocsis, A. ; Biró, É ; Rácz, É ; Kiss, A. ; Kappelmayer, J. / Mean corpuscular volume is not a reliable marker of red cell age in case of anisocytosis. In: Annals of Hematology. 1998 ; Vol. 77, No. 4. pp. 149-151.
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