Matrix metalloproteinases at key junctions in the pathomechanism of stroke

Zsolt Rottenberger, Krasimir Kolev

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Matrix metalloproteinases play a crucial role in the remodelling of the extracellular matrix through direct degradation of its structural proteins and control of extracellular signalling. The most common cause of ischemic brain damage is an atherothrombotic lesion in the supplying arteries. The progress of the atherosclerotic plaque development and the related thrombotic complications are mediated in part by matrix metalloproteinases. In addition to their role in the underlying disease, various members of this protease family are upregulated in the acute phase of ischemic brain damage as well as in the post-ischemic brain recovery following stroke. This review summarizes the current understanding of the matrix metalloproteinase-related molecular events at three stages of the ischemic cerebrovascular disease (in the atherosclerotic plaque, in the neurovascular unit of the brain and in the regenerating brain tissue).

Original languageEnglish
Pages (from-to)471-485
Number of pages15
JournalCentral European Journal of Biology
Volume6
Issue number4
DOIs
Publication statusPublished - Aug 1 2011

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Keywords

  • Atherosclerosis
  • Blood-brain barrier
  • Brain regeneration
  • Extracellular matrix
  • Ischemic damage

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)

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