Matrilin-2, an extracellular adaptor protein, is needed for the regeneration of muscle, nerve and other tissues

Éva Korpos, Ferenc Deák, I. Kiss

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The extracellular matrix (ECM) performs essential functions in the differentiation, maintenance and remodeling of tissues during development and regeneration, and it undergoes dynamic changes during remodeling concomitant to alterations in the cell-ECM interactions. Here we discuss recent data addressing the critical role of the widely expressed ECM protein, matrilin-2 (Matn2) in the timely onset of differentiation and regeneration processes in myogenic, neural and other tissue sand in tumorigenesis. As a multi adhesion adaptor protein, it interacts with other ECM proteins and integrins. Matn2 promotes neurite outgrowth, Schwann cell migration, neuromuscular junction formation, skeletal muscle and liver regeneration and skin wound healing. Matn2 deposition by myoblasts is crucial for the timely induction of the global switch toward terminal myogenic differentiation during muscle regeneration by affecting transforming growth factor beta/bone morphogenetic protein 7/Smad and other signal transduction pathways. Depending on the type of tissue and the pathomechanism, Matn2 can also promote or suppress tumor growth.

Original languageEnglish
Pages (from-to)866-869
Number of pages4
JournalNeural Regeneration Research
Volume10
Issue number6
Publication statusPublished - Jun 1 2015

Fingerprint

Matrilin Proteins
Nerve Tissue
Regeneration
Muscles
Extracellular Matrix Proteins
Extracellular Matrix
Proteins
Bone Morphogenetic Protein 7
Liver Regeneration
Neuromuscular Junction
Myoblasts
Schwann Cells
Integrins
Transforming Growth Factor beta
Wound Healing
Cell Movement
Signal Transduction
Carcinogenesis
Skeletal Muscle
Maintenance

Keywords

  • Multiple sclerosis
  • Myogenic differentiation
  • Neurite outgrowth
  • Neuromuscular junction (NMJ)
  • Schwann cells
  • TGF-β/BMP-7/Smad signaling
  • Trf3
  • Tumor suppression

ASJC Scopus subject areas

  • Developmental Neuroscience

Cite this

Matrilin-2, an extracellular adaptor protein, is needed for the regeneration of muscle, nerve and other tissues. / Korpos, Éva; Deák, Ferenc; Kiss, I.

In: Neural Regeneration Research, Vol. 10, No. 6, 01.06.2015, p. 866-869.

Research output: Contribution to journalArticle

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