Maternal use of oral contraceptives and risk of hypospadias - A population-based case-control study

Pia Wogelius, E. Puhó, Lars Pedersen, Mette Nørgaard, E. Czeizel, Henrik Toft Sørensen

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The aim of this population-based case-control study was to examine the risk of isolated hypospadias in boys born to mothers who have used oral contraceptives in early pregnancy. The study was based on data from the Hungarian Case-Control Surveillance of Congenital Abnormalities from 1980 to 1996, and included 3,038 boys with hypospadias (cases), 24,799 boys without congenital abnormalities (CA-free controls), and 11,881 boys with abnormalities other than hypospadias. We used unconditional logistic regression to adjust for birth order, maternal age, maternal employment status, maternal diabetes, and pre-eclampsia. When comparing cases with CA-free controls the OR for maternal use of OC was 1.21 (95% CI: 0.67-2.17). When comparing cases with boys with other abnormalities, the OR for maternal use of OC was 0.83 (95% CI: 0.46-1.50). Our data showed that self-reported maternal use of oral contraceptives during pregnancy was not associated with an increased risk of hypospadias in the offspring.

Original languageEnglish
Pages (from-to)777-781
Number of pages5
JournalEuropean Journal of Epidemiology
Volume21
Issue number10
DOIs
Publication statusPublished - Oct 2006

Fingerprint

Hypospadias
Oral Contraceptives
Case-Control Studies
Mothers
Population
Pregnancy
Birth Order
Maternal Age
Pre-Eclampsia
Logistic Models

Keywords

  • Case-control
  • Congenital abnormalities
  • Drug safety
  • Epidemiology
  • Pregnancy

ASJC Scopus subject areas

  • Epidemiology

Cite this

Maternal use of oral contraceptives and risk of hypospadias - A population-based case-control study. / Wogelius, Pia; Puhó, E.; Pedersen, Lars; Nørgaard, Mette; Czeizel, E.; Sørensen, Henrik Toft.

In: European Journal of Epidemiology, Vol. 21, No. 10, 10.2006, p. 777-781.

Research output: Contribution to journalArticle

Wogelius, Pia ; Puhó, E. ; Pedersen, Lars ; Nørgaard, Mette ; Czeizel, E. ; Sørensen, Henrik Toft. / Maternal use of oral contraceptives and risk of hypospadias - A population-based case-control study. In: European Journal of Epidemiology. 2006 ; Vol. 21, No. 10. pp. 777-781.
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