Maternal serum progesterone-induced blocking factor (PIBF) in the prediction of preterm birth

Igor Hudić, Babill Stray-Pedersen, Julia Szekeres-Bartho, Zlatan Fatušić, Larisa Dizdarević-Hudić, Vajdana Tomić, Beata Polgar, Bahrudin Hadžiefendić, Jasenko Fatušić

Research output: Contribution to journalArticle

15 Citations (Scopus)


The objective of this study was to analyze the maternal serum concentration of progesterone-induced blocking factor (PIBF) with regard to the prediction and the interval between sampling and the onset of preterm birth. A prospective study was conducted on a sample of 37 women with threatened pre-term birth and 41 healthy pregnant women between the 24th and 28th gestational weeks. Out of 37 patients with threatened preterm birth 11 delivered pre-term and three groups of patients were formed: the preterm delivery group, patients with threatened preterm delivery, and healthy pregnant women. In samples that were taken within 5 days before labor started (6/11, 54.5%), PIBF concentrations were significantly lower than in those obtained more than 5 days before labor (5/11, 45.5%; the mean interval between sampling and the onset of labor was 4.1 ± 1.8 days). Multiple regression analysis of the individual contributions of each observed parameter for preterm delivery demonstrated the significant contribution of a lack of PIBF to preterm birth (p = 0.002). Receiver operating characteristics (ROC) analysis was performed to evaluate the diagnostic accuracy of PIBF for the prediction of preterm birth of women with symptoms of pre-term delivery. The PIBF demonstrated an excellent diagnostic value in the prediction of preterm birth with an area under the ROC curve (AUC) of 0.956 (95% CI = 0.884-0.989; p < 0.0001). Our data suggest that pregnancy termination can be predicted by lower than normal pregnancy PIBF values within 5 days before labor and can contribute to the diagnosis of preterm birth.

Original languageEnglish
Pages (from-to)36-40
Number of pages5
JournalJournal of Reproductive Immunology
Publication statusPublished - Jun 1 2015



  • Prediction
  • Preterm birth
  • Progesterone-induced blocking factor

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

Hudić, I., Stray-Pedersen, B., Szekeres-Bartho, J., Fatušić, Z., Dizdarević-Hudić, L., Tomić, V., Polgar, B., Hadžiefendić, B., & Fatušić, J. (2015). Maternal serum progesterone-induced blocking factor (PIBF) in the prediction of preterm birth. Journal of Reproductive Immunology, 109, 36-40.