Maternal-effect loci involved in Drosophila oogenesis and embryogenesis

P element-induced mutations on the third chromosome

Manolo Bellotto, Daniel Bopp, Kirsten André Senti, Richard Burke, P. Deák, P. Maróy, Barry Dickson, Konrad Basler, Ernst Hafen

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

A collection of 1609 recessive P-lethal mutations on the third chromosome was tested in germline clones for effects on egg differentiation and embryonic development. In 164 lines, normal differentiation of the egg chamber is prevented and in 841 lines, embryos develop abnormally. This latter group of maternal-effect mutations was subdivided into 23 classes based on the cuticular phenotypes. Our collection comprises new alleles of previously characterized genes (e.g. kayak, punt, string, tramtrack). For some of the genes identified in this screen, a maternal contribution to embryonic development has not been described previously (e.g. extramacrochaete, Trithorax-like, single minded, couch potato, canoe). The genes classified in our study with a dual function during oogenesis and embryogenesis not only substantially extends the existing collection of maternal-effect genes but will also aid further understanding of how patterning of the Drosophila embryo is controlled by the maternal genome.

Original languageEnglish
Pages (from-to)149-157
Number of pages9
JournalInternational Journal of Developmental Biology
Volume46
Issue number1
Publication statusPublished - 2002

Fingerprint

Oogenesis
Drosophila
Embryonic Development
Chromosomes
Mutation
Genes
Ovum
Embryonic Structures
Mothers
Clone Cells
Alleles
Genome
Phenotype
Maternal Inheritance

Keywords

  • Dorsal closure
  • Germband etension
  • Germline clones
  • Oogenesis
  • Segmentation

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology

Cite this

Maternal-effect loci involved in Drosophila oogenesis and embryogenesis : P element-induced mutations on the third chromosome. / Bellotto, Manolo; Bopp, Daniel; Senti, Kirsten André; Burke, Richard; Deák, P.; Maróy, P.; Dickson, Barry; Basler, Konrad; Hafen, Ernst.

In: International Journal of Developmental Biology, Vol. 46, No. 1, 2002, p. 149-157.

Research output: Contribution to journalArticle

Bellotto, Manolo ; Bopp, Daniel ; Senti, Kirsten André ; Burke, Richard ; Deák, P. ; Maróy, P. ; Dickson, Barry ; Basler, Konrad ; Hafen, Ernst. / Maternal-effect loci involved in Drosophila oogenesis and embryogenesis : P element-induced mutations on the third chromosome. In: International Journal of Developmental Biology. 2002 ; Vol. 46, No. 1. pp. 149-157.
@article{ec54785c31a44746b885cbc8450e61e7,
title = "Maternal-effect loci involved in Drosophila oogenesis and embryogenesis: P element-induced mutations on the third chromosome",
abstract = "A collection of 1609 recessive P-lethal mutations on the third chromosome was tested in germline clones for effects on egg differentiation and embryonic development. In 164 lines, normal differentiation of the egg chamber is prevented and in 841 lines, embryos develop abnormally. This latter group of maternal-effect mutations was subdivided into 23 classes based on the cuticular phenotypes. Our collection comprises new alleles of previously characterized genes (e.g. kayak, punt, string, tramtrack). For some of the genes identified in this screen, a maternal contribution to embryonic development has not been described previously (e.g. extramacrochaete, Trithorax-like, single minded, couch potato, canoe). The genes classified in our study with a dual function during oogenesis and embryogenesis not only substantially extends the existing collection of maternal-effect genes but will also aid further understanding of how patterning of the Drosophila embryo is controlled by the maternal genome.",
keywords = "Dorsal closure, Germband etension, Germline clones, Oogenesis, Segmentation",
author = "Manolo Bellotto and Daniel Bopp and Senti, {Kirsten Andr{\'e}} and Richard Burke and P. De{\'a}k and P. Mar{\'o}y and Barry Dickson and Konrad Basler and Ernst Hafen",
year = "2002",
language = "English",
volume = "46",
pages = "149--157",
journal = "International Journal of Developmental Biology",
issn = "0214-6282",
publisher = "University of the Basque Country Press",
number = "1",

}

TY - JOUR

T1 - Maternal-effect loci involved in Drosophila oogenesis and embryogenesis

T2 - P element-induced mutations on the third chromosome

AU - Bellotto, Manolo

AU - Bopp, Daniel

AU - Senti, Kirsten André

AU - Burke, Richard

AU - Deák, P.

AU - Maróy, P.

AU - Dickson, Barry

AU - Basler, Konrad

AU - Hafen, Ernst

PY - 2002

Y1 - 2002

N2 - A collection of 1609 recessive P-lethal mutations on the third chromosome was tested in germline clones for effects on egg differentiation and embryonic development. In 164 lines, normal differentiation of the egg chamber is prevented and in 841 lines, embryos develop abnormally. This latter group of maternal-effect mutations was subdivided into 23 classes based on the cuticular phenotypes. Our collection comprises new alleles of previously characterized genes (e.g. kayak, punt, string, tramtrack). For some of the genes identified in this screen, a maternal contribution to embryonic development has not been described previously (e.g. extramacrochaete, Trithorax-like, single minded, couch potato, canoe). The genes classified in our study with a dual function during oogenesis and embryogenesis not only substantially extends the existing collection of maternal-effect genes but will also aid further understanding of how patterning of the Drosophila embryo is controlled by the maternal genome.

AB - A collection of 1609 recessive P-lethal mutations on the third chromosome was tested in germline clones for effects on egg differentiation and embryonic development. In 164 lines, normal differentiation of the egg chamber is prevented and in 841 lines, embryos develop abnormally. This latter group of maternal-effect mutations was subdivided into 23 classes based on the cuticular phenotypes. Our collection comprises new alleles of previously characterized genes (e.g. kayak, punt, string, tramtrack). For some of the genes identified in this screen, a maternal contribution to embryonic development has not been described previously (e.g. extramacrochaete, Trithorax-like, single minded, couch potato, canoe). The genes classified in our study with a dual function during oogenesis and embryogenesis not only substantially extends the existing collection of maternal-effect genes but will also aid further understanding of how patterning of the Drosophila embryo is controlled by the maternal genome.

KW - Dorsal closure

KW - Germband etension

KW - Germline clones

KW - Oogenesis

KW - Segmentation

UR - http://www.scopus.com/inward/record.url?scp=0036005799&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036005799&partnerID=8YFLogxK

M3 - Article

VL - 46

SP - 149

EP - 157

JO - International Journal of Developmental Biology

JF - International Journal of Developmental Biology

SN - 0214-6282

IS - 1

ER -