Maternal depression is associated with DNA methylation changes in cord blood T lymphocytes and adult hippocampi

Z. Nemoda, R. Massart, M. Suderman, M. Hallett, T. Li, M. Coote, N. Cody, Z. S. Sun, C. N. Soares, G. Turecki, M. Steiner, M. Szyf

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Depression affects 10-15% of pregnant women and has been associated with preterm delivery and later developmental, behavioural and learning disabilities. We tested the hypothesis that maternal depression is associated with DNA methylation alterations in maternal T lymphocytes, neonatal cord blood T lymphocytes and adult offspring hippocampi. Genome-wide DNA methylation of CD3+ T lymphocytes isolated from 38 antepartum maternal and 44 neonatal cord blood samples were analyzed using Illumina Methylation 450 K microarrays. Previously obtained methylation data sets using methylated DNA immunoprecipitation and array-hybridization of 62 postmortem hippocampal samples of adult males were re-analyzed to test associations with history of maternal depression. We found 145 (false discovery rate (FDR) q

Original languageEnglish
Pages (from-to)e545
JournalTranslational Psychiatry
Volume5
DOIs
Publication statusPublished - Apr 7 2015

Fingerprint

DNA Methylation
Fetal Blood
Hippocampus
Mothers
Depression
T-Lymphocytes
Methylation
Developmental Disabilities
Learning Disorders
Adult Children
Oligonucleotide Array Sequence Analysis
Immunoprecipitation
Pregnant Women
Genome

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Cellular and Molecular Neuroscience

Cite this

Maternal depression is associated with DNA methylation changes in cord blood T lymphocytes and adult hippocampi. / Nemoda, Z.; Massart, R.; Suderman, M.; Hallett, M.; Li, T.; Coote, M.; Cody, N.; Sun, Z. S.; Soares, C. N.; Turecki, G.; Steiner, M.; Szyf, M.

In: Translational Psychiatry, Vol. 5, 07.04.2015, p. e545.

Research output: Contribution to journalArticle

Nemoda, Z, Massart, R, Suderman, M, Hallett, M, Li, T, Coote, M, Cody, N, Sun, ZS, Soares, CN, Turecki, G, Steiner, M & Szyf, M 2015, 'Maternal depression is associated with DNA methylation changes in cord blood T lymphocytes and adult hippocampi', Translational Psychiatry, vol. 5, pp. e545. https://doi.org/10.1038/tp.2015.32
Nemoda, Z. ; Massart, R. ; Suderman, M. ; Hallett, M. ; Li, T. ; Coote, M. ; Cody, N. ; Sun, Z. S. ; Soares, C. N. ; Turecki, G. ; Steiner, M. ; Szyf, M. / Maternal depression is associated with DNA methylation changes in cord blood T lymphocytes and adult hippocampi. In: Translational Psychiatry. 2015 ; Vol. 5. pp. e545.
@article{b4cbb62bdd9b44b6ad7f7e3b420f40fb,
title = "Maternal depression is associated with DNA methylation changes in cord blood T lymphocytes and adult hippocampi",
abstract = "Depression affects 10-15{\%} of pregnant women and has been associated with preterm delivery and later developmental, behavioural and learning disabilities. We tested the hypothesis that maternal depression is associated with DNA methylation alterations in maternal T lymphocytes, neonatal cord blood T lymphocytes and adult offspring hippocampi. Genome-wide DNA methylation of CD3+ T lymphocytes isolated from 38 antepartum maternal and 44 neonatal cord blood samples were analyzed using Illumina Methylation 450 K microarrays. Previously obtained methylation data sets using methylated DNA immunoprecipitation and array-hybridization of 62 postmortem hippocampal samples of adult males were re-analyzed to test associations with history of maternal depression. We found 145 (false discovery rate (FDR) q",
author = "Z. Nemoda and R. Massart and M. Suderman and M. Hallett and T. Li and M. Coote and N. Cody and Sun, {Z. S.} and Soares, {C. N.} and G. Turecki and M. Steiner and M. Szyf",
year = "2015",
month = "4",
day = "7",
doi = "10.1038/tp.2015.32",
language = "English",
volume = "5",
pages = "e545",
journal = "Translational Psychiatry",
issn = "2158-3188",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Maternal depression is associated with DNA methylation changes in cord blood T lymphocytes and adult hippocampi

AU - Nemoda, Z.

AU - Massart, R.

AU - Suderman, M.

AU - Hallett, M.

AU - Li, T.

AU - Coote, M.

AU - Cody, N.

AU - Sun, Z. S.

AU - Soares, C. N.

AU - Turecki, G.

AU - Steiner, M.

AU - Szyf, M.

PY - 2015/4/7

Y1 - 2015/4/7

N2 - Depression affects 10-15% of pregnant women and has been associated with preterm delivery and later developmental, behavioural and learning disabilities. We tested the hypothesis that maternal depression is associated with DNA methylation alterations in maternal T lymphocytes, neonatal cord blood T lymphocytes and adult offspring hippocampi. Genome-wide DNA methylation of CD3+ T lymphocytes isolated from 38 antepartum maternal and 44 neonatal cord blood samples were analyzed using Illumina Methylation 450 K microarrays. Previously obtained methylation data sets using methylated DNA immunoprecipitation and array-hybridization of 62 postmortem hippocampal samples of adult males were re-analyzed to test associations with history of maternal depression. We found 145 (false discovery rate (FDR) q

AB - Depression affects 10-15% of pregnant women and has been associated with preterm delivery and later developmental, behavioural and learning disabilities. We tested the hypothesis that maternal depression is associated with DNA methylation alterations in maternal T lymphocytes, neonatal cord blood T lymphocytes and adult offspring hippocampi. Genome-wide DNA methylation of CD3+ T lymphocytes isolated from 38 antepartum maternal and 44 neonatal cord blood samples were analyzed using Illumina Methylation 450 K microarrays. Previously obtained methylation data sets using methylated DNA immunoprecipitation and array-hybridization of 62 postmortem hippocampal samples of adult males were re-analyzed to test associations with history of maternal depression. We found 145 (false discovery rate (FDR) q

UR - http://www.scopus.com/inward/record.url?scp=84927164326&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84927164326&partnerID=8YFLogxK

U2 - 10.1038/tp.2015.32

DO - 10.1038/tp.2015.32

M3 - Article

C2 - 25849984

AN - SCOPUS:84927164326

VL - 5

SP - e545

JO - Translational Psychiatry

JF - Translational Psychiatry

SN - 2158-3188

ER -