Az anyai bánásmód, az acetilkolinerg receptor gén polimorfizmusok és a dohányzáshoz társuló pszichés tünetek vizsgálata

Translated title of the contribution: Maternal bonding style, cholinergic receptor gene polymorphisms in association with smoking-related depressive symptoms

Csala Irén, P. Döme, J. Lazáry

Research output: Contribution to journalArticle

Abstract

Backgorund: There is accumulating evidence on the association between the cholinergic system and nicotine dependence (ND) in the literature and the bidirectional relationship of ND and depression. However, the molecular background of the development of ND and related affective phenotype is not clear. Methods: We recruited 255 tretament-seeking smokers into our study. For phenotyping assessments we used the Fagerstrom Nicotine Dependence Test; The Minnessotta Nicotine Withdrawal Scale; the Zung Self-Rating Depression Scale and the Parental Bonding Instrument. DNA was isolated from buccal mucosa sample and CHRNA4 and CHRNB2 gene SNPs were genotyped with MassArray Sequenom techniques. For statistical analyses ANOVA test, Mann-Whitney U test, linear regression, two-step cluster analyses and hapscore tests were performed. Results: Two-step cluster analysis revealed 3 well-differentiated subgroups among smokers based on phenotypic characteristics. One subgroup was associ­ated with the highest withdrawal and depressive scores. Frequency of the risk haplotype of CHRNA4 was significantly higher in this subgroup (p=0.019). Further, lifetime prevalence of major depression was also significantly higher in this subgroup. Besides, CHRNB2 gén vari­ants showed a significant interacting effect with maternal bonding style on suicide thoughts (p=0.005). Conclusions: Our results confirmed the genetic effect of CHRNA4 and CHRNB2 on smoking-related depression. These findings suggest that a genetically vulnerable subgroup can be distinguished among smokers and this subphenotype is more prone to withdrawal and depressive symptoms. Our data suggest that suicidal risk depends on both CHRNB2 gene variants and maternal bonding style. Pharmacogenetic concerns of CHRNA4 and CHRNB2 genes might be significant considering suicide as side effect of quitting therapy. Further pharmacogenetic investigations are requierd to clarify this possibility.

Translated title of the contributionMaternal bonding style, cholinergic receptor gene polymorphisms in association with smoking-related depressive symptoms
Original languageHungarian
Pages (from-to)189-196
Number of pages8
JournalNeuropsychopharmacologia Hungarica
Volume19
Issue number4
Publication statusPublished - Dec 1 2017

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Maternal bonding style, cholinergic receptor gene polymorphisms in association with smoking-related depressive symptoms'. Together they form a unique fingerprint.

  • Cite this