Mast cells modulate maintained neuronal activity in the thalamus in vivo

Péter Kovács, I. Hernádi, M. Wilhelm

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Single cell unit activity of 187 neurons of 24 rats were analysed to study the possible involvement of intracranial mast cells on modifying thalamic neuronal activity. Mast cells were activated with microiontophoretical application of compound 48/80. This substance did not modify the firing rate of cortical or hippocampal neurons (no mast cells are found here), however it caused excitation (70% in females, 11% in males), or inhibition (7% in females, 33% in males) on thalamic neurons, possibly due to mast cell activation. In consecutive anatomical evaluation many partially or fully degranulated mast cells were found in the recorded thalamic areas.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalJournal of Neuroimmunology
Volume171
Issue number1-2
DOIs
Publication statusPublished - Feb 2006

Fingerprint

Thalamus
Mast Cells
Neurons
p-Methoxy-N-methylphenethylamine

Keywords

  • Compound 48/80
  • Iontophoresis
  • Mast cells

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

Mast cells modulate maintained neuronal activity in the thalamus in vivo. / Kovács, Péter; Hernádi, I.; Wilhelm, M.

In: Journal of Neuroimmunology, Vol. 171, No. 1-2, 02.2006, p. 1-7.

Research output: Contribution to journalArticle

@article{3df1cd7d2a9c419d9cb356424b4cdd4b,
title = "Mast cells modulate maintained neuronal activity in the thalamus in vivo",
abstract = "Single cell unit activity of 187 neurons of 24 rats were analysed to study the possible involvement of intracranial mast cells on modifying thalamic neuronal activity. Mast cells were activated with microiontophoretical application of compound 48/80. This substance did not modify the firing rate of cortical or hippocampal neurons (no mast cells are found here), however it caused excitation (70{\%} in females, 11{\%} in males), or inhibition (7{\%} in females, 33{\%} in males) on thalamic neurons, possibly due to mast cell activation. In consecutive anatomical evaluation many partially or fully degranulated mast cells were found in the recorded thalamic areas.",
keywords = "Compound 48/80, Iontophoresis, Mast cells",
author = "P{\'e}ter Kov{\'a}cs and I. Hern{\'a}di and M. Wilhelm",
year = "2006",
month = "2",
doi = "10.1016/j.jneuroim.2005.07.026",
language = "English",
volume = "171",
pages = "1--7",
journal = "Journal of Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - Mast cells modulate maintained neuronal activity in the thalamus in vivo

AU - Kovács, Péter

AU - Hernádi, I.

AU - Wilhelm, M.

PY - 2006/2

Y1 - 2006/2

N2 - Single cell unit activity of 187 neurons of 24 rats were analysed to study the possible involvement of intracranial mast cells on modifying thalamic neuronal activity. Mast cells were activated with microiontophoretical application of compound 48/80. This substance did not modify the firing rate of cortical or hippocampal neurons (no mast cells are found here), however it caused excitation (70% in females, 11% in males), or inhibition (7% in females, 33% in males) on thalamic neurons, possibly due to mast cell activation. In consecutive anatomical evaluation many partially or fully degranulated mast cells were found in the recorded thalamic areas.

AB - Single cell unit activity of 187 neurons of 24 rats were analysed to study the possible involvement of intracranial mast cells on modifying thalamic neuronal activity. Mast cells were activated with microiontophoretical application of compound 48/80. This substance did not modify the firing rate of cortical or hippocampal neurons (no mast cells are found here), however it caused excitation (70% in females, 11% in males), or inhibition (7% in females, 33% in males) on thalamic neurons, possibly due to mast cell activation. In consecutive anatomical evaluation many partially or fully degranulated mast cells were found in the recorded thalamic areas.

KW - Compound 48/80

KW - Iontophoresis

KW - Mast cells

UR - http://www.scopus.com/inward/record.url?scp=29244465843&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=29244465843&partnerID=8YFLogxK

U2 - 10.1016/j.jneuroim.2005.07.026

DO - 10.1016/j.jneuroim.2005.07.026

M3 - Article

C2 - 16300831

AN - SCOPUS:29244465843

VL - 171

SP - 1

EP - 7

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

SN - 0165-5728

IS - 1-2

ER -