Abstract
Single cell unit activity of 187 neurons of 24 rats were analysed to study the possible involvement of intracranial mast cells on modifying thalamic neuronal activity. Mast cells were activated with microiontophoretical application of compound 48/80. This substance did not modify the firing rate of cortical or hippocampal neurons (no mast cells are found here), however it caused excitation (70% in females, 11% in males), or inhibition (7% in females, 33% in males) on thalamic neurons, possibly due to mast cell activation. In consecutive anatomical evaluation many partially or fully degranulated mast cells were found in the recorded thalamic areas.
| Original language | English |
|---|---|
| Pages (from-to) | 1-7 |
| Number of pages | 7 |
| Journal | Journal of Neuroimmunology |
| Volume | 171 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - Feb 2006 |
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Keywords
- Compound 48/80
- Iontophoresis
- Mast cells
ASJC Scopus subject areas
- Immunology
- Clinical Neurology
- Immunology and Allergy
- Neurology
Cite this
Mast cells modulate maintained neuronal activity in the thalamus in vivo. / Kovács, Péter; Hernádi, I.; Wilhelm, M.
In: Journal of Neuroimmunology, Vol. 171, No. 1-2, 02.2006, p. 1-7.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mast cells modulate maintained neuronal activity in the thalamus in vivo
AU - Kovács, Péter
AU - Hernádi, I.
AU - Wilhelm, M.
PY - 2006/2
Y1 - 2006/2
N2 - Single cell unit activity of 187 neurons of 24 rats were analysed to study the possible involvement of intracranial mast cells on modifying thalamic neuronal activity. Mast cells were activated with microiontophoretical application of compound 48/80. This substance did not modify the firing rate of cortical or hippocampal neurons (no mast cells are found here), however it caused excitation (70% in females, 11% in males), or inhibition (7% in females, 33% in males) on thalamic neurons, possibly due to mast cell activation. In consecutive anatomical evaluation many partially or fully degranulated mast cells were found in the recorded thalamic areas.
AB - Single cell unit activity of 187 neurons of 24 rats were analysed to study the possible involvement of intracranial mast cells on modifying thalamic neuronal activity. Mast cells were activated with microiontophoretical application of compound 48/80. This substance did not modify the firing rate of cortical or hippocampal neurons (no mast cells are found here), however it caused excitation (70% in females, 11% in males), or inhibition (7% in females, 33% in males) on thalamic neurons, possibly due to mast cell activation. In consecutive anatomical evaluation many partially or fully degranulated mast cells were found in the recorded thalamic areas.
KW - Compound 48/80
KW - Iontophoresis
KW - Mast cells
UR - http://www.scopus.com/inward/record.url?scp=29244465843&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=29244465843&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2005.07.026
DO - 10.1016/j.jneuroim.2005.07.026
M3 - Article
C2 - 16300831
AN - SCOPUS:29244465843
VL - 171
SP - 1
EP - 7
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
IS - 1-2
ER -