Tömegspektrometria: múlt és jelen

Translated title of the contribution: Mass spectrometry: past and present

Márton Király, Borbála Dalmadiné Kiss, Károly Vékey, István Antal, Krisztina Ludányi

Research output: Contribution to journalReview article

Abstract

Mass spectrometry is a highly sensitive high-throughput instrumental analytical technique. It is used to determine the molecular mass, but also gives information on molecular structure amd is used for quantitation as well. Although it was developed over 100 years ago, it continues to evolve, both with respect to figures of merit (like sensitivity) and with respect to applications in various novel fields of science and technology. Mass spectrometry is capable of studying macromolecules (like proteins and protein complexes), and has very high sensitivity, now compounds at the atto- or zeptomol level can also be studied. Mass spectrometry can be coupled to separation techniques, and can be used to analyze complex mixtures, trace level compounds in biological matrices like active pharmaceutical ingredients or metabolites. In recent years in proteomics research has become a major new direction. In the present review we briefly introduce basic mass spectrometry techniques (ion surces, analyzers), combinations with chromatography (GC/MS, HPLC/MS), CEI MS) and tandem mass spectrometry. We also introduce two novel methods, mass spectrometry "imaging" and "lab-on-a-chip" technology.

Original languageHungarian
Pages (from-to)3-11
Number of pages9
JournalActa Pharmaceutica Hungarica
Volume86
Issue number1
Publication statusPublished - 2016

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Mass Spectrometry
Technology
Tandem Mass Spectrometry
Molecular Structure
Complex Mixtures
Proteomics
Chromatography
Proteins
High Pressure Liquid Chromatography
Ions
Research
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Tömegspektrometria : múlt és jelen. / Király, Márton; Dalmadiné Kiss, Borbála; Vékey, Károly; Antal, István; Ludányi, Krisztina.

In: Acta Pharmaceutica Hungarica, Vol. 86, No. 1, 2016, p. 3-11.

Research output: Contribution to journalReview article

Király, M, Dalmadiné Kiss, B, Vékey, K, Antal, I & Ludányi, K 2016, 'Tömegspektrometria: múlt és jelen', Acta Pharmaceutica Hungarica, vol. 86, no. 1, pp. 3-11.
Király, Márton ; Dalmadiné Kiss, Borbála ; Vékey, Károly ; Antal, István ; Ludányi, Krisztina. / Tömegspektrometria : múlt és jelen. In: Acta Pharmaceutica Hungarica. 2016 ; Vol. 86, No. 1. pp. 3-11.
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