Mass spectrometry of thermorubin antibiotics

Duncan M.F. Edwards, Károly Vékey, Marina Galimberti

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Abstract

Different soft introduction and ionization methods, including fast atom bombardment, particle beam chemical ionization, thermospray and direct liquid introduction (DLI) have been compared for the analysis of thermorubin, a thermally labile antibiotic of molecular weight 600. Emphasis is placed on distinguishing thermally induced processes, which may complicate the interpretation of liquid chromatographic mass spectra of synthetic derivatives: the study draws in particular on results of DLI negative ion experiments on thermorubin and related compounds.

Original languageEnglish
Pages (from-to)43-50
Number of pages8
JournalBiological Mass Spectrometry
Volume21
Issue number1
DOIs
Publication statusPublished - Jan 1992

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine

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