MARS therapy, the bridging to liver retransplantation-Three cases from the Hungarian liver transplant program

Balázs Pocze, János Fazakas, Gergely Zádori, Dénes Görög, L. Kóbori, Eszter Dabasi, Tamás Mándli, László Piros, Anikó Smudla, Tamás Szabó, Éva Toronyi, Szabolcs Tóth, Gellért Tozsér, Gyula Végso, Attila Doros, B. Nemes

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4 Citations (Scopus)

Abstract

Besides orthotopic liver transplantation (OLT) there is no long-term and effective replacement therapy for severe liver failure. Artificial extracorporeal liver supply devices are able to reduce blood toxin levels, but do not replace any synthetic function of the liver. Molecular adsorbent recirculating system (MARS) is one of the methods that can be used to treat fulminant acute liver failure (ALF) or acute on chronic liver failure (AoCLF). The primary non-function (PNF) of the newly transplanted liver manifests in the clinical settings exactly like acute liver failure. MARS treatment can reduce the severity of complications by eliminating blood toxins, so that it can help hepatic encephalopathy (HE), hepatorenal syndrome (HRS), and the high rate mortality of cerebral herniation. This might serve as a bridging therapy before orthotopic liver retransplantation (reOLT). Three patients after a first liver transplantation became candidate for urgent MARS treatment as a bridging solution prior to reOLT in our center. Authors report these three cases, focusing on indications, MARS sessions, clinical courses, and final outcomes.

Original languageEnglish
Pages (from-to)70-75
Number of pages6
JournalInterventional Medicine and Applied Science
Volume5
Issue number2
DOIs
Publication statusPublished - Jun 1 2013

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Keywords

  • liver failure
  • MARS therapy
  • retransplantation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Pocze, B., Fazakas, J., Zádori, G., Görög, D., Kóbori, L., Dabasi, E., Mándli, T., Piros, L., Smudla, A., Szabó, T., Toronyi, É., Tóth, S., Tozsér, G., Végso, G., Doros, A., & Nemes, B. (2013). MARS therapy, the bridging to liver retransplantation-Three cases from the Hungarian liver transplant program. Interventional Medicine and Applied Science, 5(2), 70-75. https://doi.org/10.1556/IMAS.5.2013.2.3