Markers of coagulation and fibrinolysis predicting the outcome of acute ischemic stroke thrombolysis treatment: A review of the literature

Z. Bagoly, István Szegedi, Rita Kálmándi, Noémi Klára Tóth, L. Csiba

Research output: Contribution to journalReview article

Abstract

Intravenous administration of recombinant tissue plasminogen activator (rt-PA) has been proven to be safe and effective in the treatment of acute ischemic stroke. Little is known, however, why this treatment is less effective in some patients while in others life-threatening side-effects, e.g., symptomatic intracerebral hemorrhage might occur. Clinical failure of thrombolysis related to absent or partial recanalization or reocclusion as well as hemorrhagic complications of thrombolysis are possibly related to hemostatic events. Data on markers of coagulation and/or fibrinolysis in acute stroke patients are numerous and may provide indications regarding therapy outcomes. Better understanding of the hemostatic and fibrinolytic system during rt-PA therapy might be clinically useful and ultimately might lead to an improvement in the efficacy or safety of this treatment. Studies on thrombus composition retrieved from cerebral arteries may also advance our knowledge and provide a key to improve acute stroke therapy. Here we provide a comprehensive review on a wide range of factors and markers of coagulation and fibrinolysis that have been studied in the context of thrombolysis outcome in ischemic stroke patients. Moreover, a brief summary is given on the most recent research on thrombus composition having a potential influence on outcomes.

Original languageEnglish
Article number513
JournalFrontiers in Neurology
Volume10
Issue numberJUN
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Fibrinolysis
Stroke
Tissue Plasminogen Activator
Hemostatics
Thrombosis
Therapeutics
Cerebral Arteries
Blood Coagulation Factors
Cerebral Hemorrhage
Intravenous Administration
Safety
Research

Keywords

  • Coagulation
  • Fibrinolysis
  • Outcome
  • Stroke
  • Thrombolysis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Markers of coagulation and fibrinolysis predicting the outcome of acute ischemic stroke thrombolysis treatment : A review of the literature. / Bagoly, Z.; Szegedi, István; Kálmándi, Rita; Tóth, Noémi Klára; Csiba, L.

In: Frontiers in Neurology, Vol. 10, No. JUN, 513, 01.01.2019.

Research output: Contribution to journalReview article

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